Coronary CT angiography-derived fractional flow reserve in-stable angina: association with recurrent chest pain
| Autor: | Kristian Tækker Madsen, Niels Peter Rønnow Sand, Lisette Okkels Jensen, Allan Rohold, Kristian Korsgaard Thomsen, Majed Husain, Karsten Tange Veien, Martin Weber Kusk, Lone Deibjerg, Pia Veldt Larsen, Anders Junker |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Computed Tomography Angiography medicine.medical_treatment Fractional flow reserve Coronary Artery Disease Chest pain Revascularization Coronary Angiography Stable angina Severity of Illness Index Predictive Value of Tests Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Angina Stable business.industry Coronary computed tomography angiography Coronary Stenosis General Medicine Coronary Vessels Coronary arteries Fractional Flow Reserve Myocardial medicine.anatomical_structure Cardiology medicine.symptom Abnormality Cardiology and Cardiovascular Medicine business Artery |
| Zdroj: | European heart journal. Cardiovascular Imaging. 23(11) |
| ISSN: | 2047-2412 |
| Popis: | Aims The aim of this study was to evaluate the association between coronary computed tomography angiography (CCTA)-derived fractional flow reserve (FFRCT) and recurrent chest pain (CP) at 1-year follow-up in patients with stable angina pectoris (SAP). Methods and results Study of patients (n = 267) with SAP who underwent CCTA and FFRCT testing; 236 (88%) underwent invasive coronary angiography; and 87 (33%) were revascularized. Symptomatic status at 1-year follow-up was gathered by a structured interview. Three different FFRCT algorithms were applied using the following criteria for abnormality: (i) 2 cm-FFRCT ≤0.80; (ii) d-FFRCT ≤0.80; and (iii) a combination in which both a d-FFRCT ≤0.80 and a ΔFFRCT ≥0.06 must be present in the same vessel (c-FFRCT). Patients were classified into two groups based on the FFRCT test result and revascularization: completely revascularized/normal (CRN), patients in whom all coronary arteries with an abnormal FFRCT test result were revascularized or patients with completely normal FFRCT test results, and incompletely revascularized (IR), patients in whom ≥1 coronary artery with an abnormal FFRCT test result was not revascularized. Recurrent CP was present in 62 (23%) patients. Classification of patients (CRN or IR) was significantly associated with recurrent CP for all applied FFRCT interpretation algorithms. When applying the c-FFRCT algorithm, the association with recurrent CP was found, irrespective of the extent of coronary calcification and the degree of coronary stenosis. A negative association between per-patient minimal d-FFRCT and recurrent CP was demonstrated, P < 0.005. Conclusion An abnormal FFRCT test result is associated with an increased risk of recurrent CP in patients with new-onset SAP. |
| Databáze: | OpenAIRE |
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