Comparison of procalcitonin and C-reactive protein as early diagnostic marker for the identification of transplant-related adverse events after allogeneic hematopoietic stem cell transplantation in pediatric patients

Autor:	Karin Melanie Cabanillas Stanchi, Patrick Schlegel, Ingo Müller, Christian Seitz, Markus Dobratz, Carmen Malaval, Judith Feucht, Rupert Handgretinger, Manon Queudeville, Michaela Döring, Peter Lang
Rok vydání:	2019
Předmět:	0301 basic medicine Graft Rejection Male Cancer Research medicine.medical_specialty Adolescent medicine.medical_treatment Graft vs Host Disease Bacteremia Hematopoietic stem cell transplantation Gastroenterology Procalcitonin Sepsis 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Mucositis Humans Transplantation Homologous Child Fungemia Retrospective Studies Hematology biology business.industry C-reactive protein Hematopoietic Stem Cell Transplantation Infant General Medicine medicine.disease Prognosis 030104 developmental biology C-Reactive Protein Early Diagnosis Oncology 030220 oncology & carcinogenesis Case-Control Studies Child Preschool Hematologic Neoplasms biology.protein Female business Biomarkers Follow-Up Studies
Zdroj:	Journal of cancer research and clinical oncology. 145(11)
ISSN:	1432-1335
Popis:	To evaluate serum procalcitonin (PCT) and C-reactive protein (CRP) as diagnostic biomarkers of transplant-related adverse events (TRAE) in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT). This study analyzed PCT and CRP levels of 214 pediatric patients with a median age of 8.5 years (0.4–17.8 years) undergoing allogeneic HSCT with respect to major TRAE. 26 patients (12.1%) did not experience TRAE (control group), and 188 (87.9%) experienced median 2 (range 1–4) TRAE. Median CRP and PCT were highly and significantly increased during sepsis/SIRS and bacteremia (17.24 mg/dl | 6.30 ng/ml; p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d5918e995586ce8ad89b06858c5d79 https://pubmed.ncbi.nlm.nih.gov/31446489 Zobrazit plný text záznamu Full text from SpringerLink