Role of IgG against N-protein of SARS-CoV2 in COVID19 clinical outcomes
| Autor: | Justin Nestor Miranda, Camila Sofia Sacher, Justin Rafa O. De La Fuente, Mehdi Mirsaeidi, D.R. Green, Megan Mathew, Huda Asif, Mohammad Ali Faghihi, Runxia Tian, Emile Clarence, Shweta Kambali, Mayank Batra, Chongxu Zhang, Sayari Patel, Maria Virginia Perez Bastidas, Miguel Santiago Gonzalez, K. Santos, Mukunthan Murthi, Farzaneh Modarresi, Sara Haddadi |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine Prognostic factor medicine.medical_specialty Science Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Lymphocyte Immunology Diseases Disease Antibodies Viral Logistic regression Gastroenterology Article Immunoglobulin G 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine Aged Aged 80 and over Multidisciplinary biology SARS-CoV-2 business.industry Viral core Clinical course COVID-19 Length of Stay Middle Aged Nucleocapsid Proteins Prognosis Intensive Care Units Titer 030104 developmental biology medicine.anatomical_structure Spike Glycoprotein Coronavirus biology.protein Medicine Female Antibody business |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-021-83108-0 |
| Popis: | The Nucleocapsid Protein (N Protein) of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV2) is located in the viral core. Immunoglobulin G (IgG) targeting N protein is detectable in the serum of infected patients. The effect of high titers of IgG against N-protein on clinical outcomes of SARS-CoV2 disease has not been described. We studied 400 RT-PCR confirmed SARS-CoV2 patients to determine independent factors associated with poor outcomes, including Medical Intensive Care Unit (MICU) admission, prolonged MICU stay and hospital admissions, and in-hospital mortality. We also measured serum IgG against the N protein and correlated its concentrations with clinical outcomes. We found that several factors, including Charlson comorbidity Index (CCI), high levels of IL6, and presentation with dyspnea were associated with poor clinical outcomes. It was shown that higher CCI and higher IL6 levels were independently associated with in-hospital mortality. Anti-N protein IgG was detected in the serum of 55 (55%) patients at the time of admission. A high concentration of antibodies, defined as signal to cut off ratio (S/Co) > 1.5 (75 percentile of all measurements), was found in 25 (25%) patients. The multivariable logistic regression models showed that between being an African American, higher CCI, lymphocyte counts, and S/Co ratio > 1.5, only S/Co ratio were independently associated with MICU admission and longer length of stay in hospital. This study recommends that titers of IgG targeting N-protein of SARS-CoV2 at admission is a prognostic factor for the clinical course of disease and should be measured in all patients with SARS-CoV2 infection. |
| Databáze: | OpenAIRE |
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