Genetic linkage analysis of collagen-induced arthritis in the mouse
| Autor: | Johan Jirholt, Andrew D. Cook, Tesfai Emahazion, Liselotte Jansson, Mats Sundvall, Ulf Pettersson, Niklas Nordquist, Rikard Holmdahl |
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| Rok vydání: | 1998 |
| Předmět: |
Male
musculoskeletal diseases Genetic Linkage Immunology Arthritis Locus (genetics) Major histocompatibility complex Arthritis Rheumatoid Mice medicine Animals Immunology and Allergy Genetic Predisposition to Disease Genetic Testing Chromosome 13 Genetics biology Chromosome Mapping medicine.disease Chromosome 17 (human) Disease Models Animal Chromosome 3 biology.protein Microsatellite Female Collagen Gene polymorphism Microsatellite Repeats |
| Zdroj: | European Journal of Immunology. 28:3321-3328 |
| ISSN: | 1521-4141 0014-2980 |
| DOI: | 10.1002/(sici)1521-4141(199810)28:10<3321::aid-immu3321>3.0.co;2-m |
| Popis: | The genetic susceptibility to collagen-induced arthritis (CIA) in mice, the most commonly used model for rheumatoid arthritis, has been analyzed. The highly susceptible B10.RIII strain was crossed with the resistant RIIIS/J strain and the F2 intercross mice were subjected to genomic screening using microsatellite markers. These strains share the MHC region on chromosome 17, known to be of importance in CIA (this locus is named Mcia1). The same cross has earlier been used to map the major genes outside the MHC controlling chronic relapsing experimental allergic encephalomyelitis (EAE). It was found that the major locus controlling CIA (Mcia2; lod 4.12) was located on chromosome 3 in the same region as one of the major loci controlling EAE (Eae3). The linkage was reproduced in a mouse strain in which the locus was isolated on the B10.RIII background at the N4I2 generation. A second putative locus was identified on chromosome 13 (lod 3.13). The present finding identifies new loci outside the MHC controlling CIA and provides evidence that mouse CIA is controlled by polymorphic genes. |
| Databáze: | OpenAIRE |
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