Population Genetic Structure and Isolation by Distance of Helicobacter pylori in Senegal and Madagascar
| Autor: | Jean-Michel Thiberge, Josette Raymond, Benoit Garin, Rado Manitrala Ramanampamonjy, Bodo Linz, D. Dia, Sébastien Breurec, Jean-François Carod, Abdoulaye Seck, Clairette Romaine Raharisolo Vololonantenainab |
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| Přispěvatelé: | Department of Biochemistry and Molecular Biology, Pennsylvania State University (Penn State), Penn State System-Penn State System, Laboratoire d’Anatomie et de Cytologie Pathologiques, Institut Pasteur de Madagascar, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Laboratoire de Biologie Médicale [Dakar, Sénégal], Institut Pasteur de Dakar, Centre de Biologie Clinique [Antananarivo] (IPM), Département de Gastro-entérologie, Centre Hospitaler Le Dantec, Unité de Bactériologie Expérimentale [Antananarivo, Madagascar] (IPM), Centre Hospitalier Universitaire Joseph Ravoahangy Befelatanana, Génotypage des Pathogènes et Santé Publique (Plate-forme) (PF8), Institut Pasteur [Paris], Pathogenèse de Helicobacter, Laboratoire de Biologie médicale, Institut Pasteur de Bangui, This study was supported by grants from Institut Pasteur (ACIP Helicobacter pylori) and the ERA-NET PathoGenoMics (project HELDIVNET, decision n°ANR-06-PATHO-007-01)., Institut Pasteur [Paris] (IP) |
| Rok vydání: | 2014 |
| Předmět: |
lcsh:Medicine
Population genetics 0302 clinical medicine Gram Negative Genome Sequencing lcsh:Science Phylogeny Helicobacter pylori/isolation & purification Helicobacter Infections/microbiology Aged 80 and over 2. Zero hunger Genetics 0303 health sciences education.field_of_study Multidisciplinary Geography Population Groups/genetics Genomics Middle Aged Helicobacter pylori/genetics Senegal Bacterial Pathogens [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology Genetic Variation/genetics Genetic structure Medicine 030211 gastroenterology & hepatology Genetic isolate Research Article Adult Adolescent Human Migration Population Black People Zoology Gastroenterology and Hepatology Biology Human Geography Southeast asian Microbiology Helicobacter Infections Helicobacter Infections/genetics Young Adult 03 medical and health sciences Population Groups Genetic variation Madagascar Humans education GeneticsPopulation/methods Aged 030304 developmental biology Isolation by distance Evolutionary Biology Genetic diversity Helicobacter pylori lcsh:R Genetic Variation African Continental Ancestry Group/genetics Endoscopy Organismal Evolution Genetics Population Aged 80 and over Microbial Evolution Earth Sciences lcsh:Q Population Genetics Geography/methods |
| Zdroj: | PLoS ONE PLoS ONE, Public Library of Science, 2013, 9 (1), pp.e87355. ⟨10.1371/journal.pone.0087355⟩ PLoS ONE, Vol 9, Iss 1, p e87355 (2014) PLoS ONE, 2013, 9 (1), pp.e87355. ⟨10.1371/journal.pone.0087355⟩ |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0087355 |
| Popis: | International audience; Helicobacter pylori has probably infected the human stomach since our origins and subsequently diversified in parallel with their human hosts. The genetic population history of H. pylori can therefore be used as a marker for human migration. We analysed seven housekeeping gene sequences of H. pylori strains isolated from 78 Senegalese and 24 Malagasy patients and compared them with the sequences of strains from other geographical locations. H. pylori from Senegal and Madagascar can be placed in the previously described HpAfrica1 genetic population, subpopulations hspWAfrica and hspSAfrica, respectively. These 2 subpopulations correspond to the distribution of Niger-Congo speakers in West and most of subequatorial Africa (due to Bantu migrations), respectively. H. pylori appears as a single population in Senegal, indicating a long common history between ethnicities as well as frequent local admixtures. The lack of differentiation between these isolates and an increasing genetic differentiation with geographical distance between sampling locations in Africa was evidence for genetic isolation by distance. The Austronesian expansion that started from Taiwan 5000 years ago dispersed one of the 10 subgroups of the Austronesian language family via insular Southeast Asia into the Pacific and Madagascar, and hspMaori is a marker for the entire Austronesian expansion. Strain competition and replacement of hspMaori by hpAfrica1 strains from Bantu migrants are the probable reasons for the presence of hspSAfrica strains in Malagasy of Southeast Asian descent. hpAfrica1 strains appear to be generalist strains that have the necessary genetic diversity to efficiently colonise a wide host spectrum. |
| Databáze: | OpenAIRE |
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