Molecular evidence of hybridization between pig and human Ascaris indicates an interbred species complex infecting humans
| Autor: | Stella Kepha, Rita G. Oliveira, Joanne P. Webster, Jianbin Wang, Asis Khan, Scott P. Lawton, Thomas B. Nutman, Roy M. Anderson, Michael E. Grigg, Eric Dahlstrom, Sasisekhar Bennuru, Stephen F. Porcella, Shenghan Gao, Richard E. Davis, Alice V. Easton |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
QH301-705.5 Science 030231 tropical medicine global health Genomics 0601 Biochemistry and Cell Biology Genome General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Phylogenetics Ascariasis parasitic diseases genomics medicine genetics human Biology (General) Ascaris lumbricoides species complex Ascaris suum reference genome Genetics General Immunology and Microbiology biology Ascaris General Neuroscience General Medicine biology.organism_classification medicine.disease zoonoses 3. Good health 030104 developmental biology Medicine epidemiology Reference genome |
| Zdroj: | eLife, Vol 9 (2020) |
| ISSN: | 2050-084X |
| DOI: | 10.7554/elife.61562 |
| Popis: | Human ascariasis is a major neglected tropical disease caused by the nematodeAscaris lumbricoides. We report a 296 megabase (Mb) reference-quality genome comprised of 17,902 protein-coding genes derived from a single, representativeAscarisworm. An additional 68 worms were collected from 60 human hosts in Kenyan villages where pig husbandry is rare. Notably, the majority of these worms (63/68) possessed mitochondrial genomes that clustered closer to the pig parasiteAscaris suumthan toA. lumbricoides. Comparative phylogenomic analyses identified over 11 million nuclear-encoded SNPs but just two distinct genetic types that had recombined across the genomes analyzed. The nuclear genomes had extensive heterozygosity, and all samples existed as genetic mosaics with eitherA. suum-like orA. lumbricoides-like inheritance patterns supporting a highly interbredAscarisspecies genetic complex. As no barriers appear to exist for anthroponotic transmission of these ‘hybrid’ worms, a one-health approach to control the spread of human ascariasis will be necessary. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|