High early uterine vascular resistance values increase the risk of adverse pregnancy outcome independently from placental VEGF and VEGFR1 reactivities
| Autor: | János Gidai, Júlia Németh, Z. Schaff, Peter Toth, Sándor Valent, Levente Sara, Attila Pajor, Ferenc Paulin |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Vascular Endothelial Growth Factor A medicine.medical_specialty Placenta Uterus Andrology Pregnancy medicine Humans Decidual cells Prospective Studies Vascular Endothelial Growth Factor Receptor-1 Obstetrics business.industry Obstetrics and Gynecology Trophoblast medicine.disease Pregnancy Complications Pregnancy Trimester First Uterine Artery medicine.anatomical_structure Cross-Sectional Studies Reproductive Medicine In utero Vascular resistance Gestation Female Vascular Resistance business Follow-Up Studies |
| Zdroj: | European journal of obstetrics, gynecology, and reproductive biology. 156(2) |
| ISSN: | 1872-7654 |
| Popis: | Objective From data in the literature, we hypothesized that high vascular resistance values in the uterine arteries at the end of the first trimester would increase adverse pregnancy outcomes and therefore might be accompanied by changes in VEGF/VEGFR1 immunoreactivities. Study design In our university hospital 82 women (Study I n = 62 and Study II n = 20) were divided into two groups according to their uterine vascular resistance values. Uterine vascular resistance values were measured in the 10–13th weeks of gestation by color-Doppler ultrasonography. Women were divided into low and high vascular resistance groups. In the prospective follow-up study (Study I) the data of the pregnancy outcome were recorded. In cross-sectional study (Study II), VEGF and VEGFR1 immunoreactivities were measured on the tissue samples from women who underwent termination of pregnancy. Results In the high vascular resistance group (PI > 2.3), the probability of adverse pregnancy outcome was significantly higher (40.0% vs. 12.8%). No differences in VEGF and VEGFR1 immunoreactivities were observed between groups. In both groups, intense VEGF immunoreactivity was observed in the maternal glandular epithelium and in the decidual cells. Weak reactivity was observed in the villous trophoblast. VEGFR1 immunoreactivity was intense in all regions. Conclusions Our data suggest that high vascular resistance values in the first trimester are independent from VEGF/VEGFR1 immunoreactivities and markedly increase the probability of adverse pregnancy outcomes. This may be used for early screening of pregnant women in the first trimester. |
| Databáze: | OpenAIRE |
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