Emerging Role of Transient Receptor Potential Vanilloid 4 (TRPV4) Ion Channel in Acute and Chronic Itch
| Autor: | Gwendolyn Henry, Yong Chen, Qiaojuan Zhang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
keratinocytes
0301 basic medicine TRPV4 QH301-705.5 TRPV1 TRPV Cation Channels Sensory system Review Olfaction Catalysis Inorganic Chemistry 03 medical and health sciences Transient receptor potential channel 0302 clinical medicine Stimulus modality otorhinolaryngologic diseases Animals Humans Medicine itch Biology (General) Physical and Theoretical Chemistry Chronic itch pruritogen QD1-999 Molecular Biology Spectroscopy Ion channel business.industry Pruritus Organic Chemistry General Medicine Computer Science Applications Chemistry sensory neurons 030104 developmental biology Acute Disease Chronic Disease business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 7591, p 7591 (2021) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms22147591 |
| Popis: | Itch is a clinical problem that leaves many sufferers insufficiently treated, with over 20 million cases in the United States. This is due to incomplete understanding of its molecular, cellular, and cell-to-cell signaling mechanisms. Transient receptor potential (TRP) ion channels are involved in several sensory modalities including pain, vision, taste, olfaction, hearing, touch, and thermosensation, as well as itch. Relative to the extensive studies on TRPV1 and TRPA1 ion channels in itch modulation, TRPV4 has received relatively little research attention and its mechanisms have remained poorly understood until recently. TRPV4 is expressed in ganglion sensory neurons and a variety of skin cells. Growing evidence in the past few years strongly suggests that TRPV4 in these cells contributes to acute and chronic disease-associated itch. This review focuses on the current experimental evidence involving TRPV4 in itch under pathophysiological conditions and discusses its possible cellular and molecular mechanisms. |
| Databáze: | OpenAIRE |
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