Tracing the evolutionary origin of the TFF-domain, an ancient motif at mucous surfaces
| Autor: | Nikolaus Blin, Peter Gött, Patricia Sommer |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
endocrine system
Chromosomes Human Pair 21 Molecular Sequence Data Muscle Proteins Biology Evolution Molecular Genetics medicine Consensus sequence Animals Humans Amino Acid Sequence Urochordata Growth Substances education Zona pellucida Peptide sequence chemistry.chemical_classification education.field_of_study Sequence Homology Amino Acid Trefoil factor 3 Neuropeptides Mucin Mucins Trefoil factor 2 Chromosome Mapping Exons General Medicine Open reading frame medicine.anatomical_structure chemistry embryonic structures Trefoil Factor-2 Trefoil Factor-3 Peptides Glycoprotein |
| Zdroj: | Gene. 236:133-136 |
| ISSN: | 0378-1119 |
| DOI: | 10.1016/s0378-1119(99)00243-7 |
| Popis: | Mammalian trefoil factor family (TFF)-domain peptides promote gastrointestinal protection, healing and cell migration and may act as tumour suppressors. TFF-like domains also constitute modules of composite proteins like mucin glycoproteins and zona pellucida proteins. Database searches with a modified, less stringent consensus sequence - C-x(5,6)-[ST]-x(3)-C-x(4,5)-C-C-[FYWH]-x(2, 24)-C-[FY] - revealed that ancestors of the TFF-domain arose before amphibian evolution. Eggshell proteins and a zona pellucida-like protein in teleost species, an epidermis-specific protein in a tunicate as well as an open reading frame in a nematode exhibited TFF-like motifs suggesting that they most likely originated in some multicellular organism. |
| Databáze: | OpenAIRE |
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