Influence of T-593 on the recurence and relapse of cryocautery-induced gastric ulcer in rats: Sequential observation with an endoscope and histological evaluation
| Autor: | Kazuhiko Hashiba, Yasuko Doi, Midori Mizuo, Yukio Mori, Hirotoshi Arai, Shigeki Marubuchi, Mihoko Syouji |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Ulcer healing Drug medicine.medical_specialty Endoscope media_common.quotation_subject Cautery Cryocautery Ranitidine Ulcer index Cryosurgery Guanidines Gastroenterology Recurrence Internal medicine medicine Animals Stomach Ulcer Sulfones Rats Wistar media_common Pharmacology business.industry Endoscopy Anti-Ulcer Agents Famotidine digestive system diseases Rats Clinical therapy Histamine H2 Antagonists business medicine.drug |
| Zdroj: | Folia Pharmacologica Japonica. 112:381-393 |
| ISSN: | 1347-8397 0015-5691 |
| DOI: | 10.1254/fpj.112.381 |
| Popis: | We investigated the influence of T-593, a novel anti-ulcer agent, on the recurrence and relapse of cryocautery-induced gastric ulcer in rats, in comparison with the action of famotidine and ranitidine. The drugs were administered from the 7th to the 119th day and then discontinued to the 190th day after induction of gastric ulcer. The healing, recurrence and relapse process of gastric ulcer was sequentially observed with an endoscope. In the control group, the reduction of ulcer index was observed until the 76th day after ulcer induction followed by aggravation, suggesting the recurrence and relapse occurred on cryocautery-induced gastric ulcer in rats. In the famotidine and ranitidine groups, the recurrence and relapse occurred after cessation of administration. The recurrence and/or relapse rate of T-593 was lower than those of other drugs. In the histological measurement, the grades of heterotopic regenerated gland and inflammatory cell infiltration of T-593 was lower than those of the control and other drugs in the ulcer area. From these results, it is concluded that T-593 induces ulcer healing with a lower recurrence and/or relapse rate of ulcers than other conventional H2-antagonists, and T-593 may thus be a useful anti-ulcer drug for clinical therapy. |
| Databáze: | OpenAIRE |
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