A Systematic Review on the Association of Acquired Human Cytomegalovirus Infection with Hearing Loss

Autor: Patricia Perez-Carpena, Marisa Flook, Jose A. Lopez-Escamez, Estrella Martínez-Gómez
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Clinical Medicine
Journal of Clinical Medicine, Vol 9, Iss 4011, p 4011 (2020)
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digibug. Repositorio Institucional de la Universidad de Granada
instname
ISSN: 2077-0383
0356-2018
Popis: Congenital cytomegalovirus (CMV) infection induces a clinical syndrome usually associated with hearing loss. However, the e ect of acquired CVM infection in adults and children has not been clearly defined. The objective of this review is to critically appraise scientific evidence regarding the association of acquired CMV infection with postnatal hearing loss or tinnitus. A systematic review of records reporting sensorineural hearing loss (SNHL) or tinnitus and acquired CMV infection including articles published in English was performed. Search strategy was limited to human studies with acquired CMV infection. After screening and quality assessment, nine studies involving 1528 individuals fulfilled the inclusion criteria. A total of 14% of patients with SNHL showed evidence of previous exposure to CMV, while in individuals without SNHL (controls) the percentage rose up to 19.3%. SNHL was reported as unilateral or bilateral in 15.3%, and not specified in 84.7% of cases. The degree of SNHL ranged from mild to profound for both children and adults. None of the records reported tinnitus. The prevalence of children or adults with acquired SNHL with a confirmed acquired CMV infection by Polymerase Chain Reaction (PCR) or IgM anti-CMV antibodies is low. Phenotyping of patients with acquired CMV infection was limited to hearing loss by pure tone audiometry and no additional audiological testing was performed in most of the studies. Additional symptoms deserve more attention, including episodic vertigo or tinnitus, since some patients with the clinical spectrum of Meniere Disease could result from a CMV latent infection.
Instituto de Salud Carlos III
European Regional Funds PI17/1644 PE-0356-2018
"IN VITRO PRECLINICAL TRIAL AND MONITORIN OF CLINICAL RESPONSE IN PATIENTS WITH MENIERE DISEASE (CLINMON)" from Andalusian Health Government PE-0356-2018
Instituto de Salud Carlos III FI18/00228
Databáze: OpenAIRE
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