Overall major histocompatibility complex class I expression is not downregulated in cervix cancer, as detected by immunoelectron microscopy
| Autor: | M. A. Van Eijkeren, Hans J. Geuze, J. P. Roovers, V. Oorschot |
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| Přispěvatelé: | Obstetrics and Gynaecology, University of Groningen |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Adult
squamous cervix cancer Pathology medicine.medical_specialty TUMOR-CELLS Immunoelectron microscopy Antigen presentation Uterine Cervical Neoplasms Cervix Uteri Major histocompatibility complex PATHWAY MOLECULES immunoelectron microscopy Cell Line Tumor MHC class I ANTIGEN PRESENTATION medicine Humans Cervix Aged LESIONS biology major histocompatibility complex class I TRANSPORTER Histocompatibility Antigens Class I Obstetrics and Gynecology Cancer Epithelial Cells Immunogold labelling Middle Aged medicine.disease GENE Immunohistochemistry Molecular biology MHC CLASS-I medicine.anatomical_structure Oncology CARCINOMAS Case-Control Studies Cancer cell Carcinoma Squamous Cell biology.protein Female LEUKOCYTE ANTIGENS |
| Zdroj: | International journal of gynecological cancer, 14(2), 317-321. Wolters Kluwer Health International Journal of Gynecological Cancer, 14(2), 317-321. LIPPINCOTT WILLIAMS & WILKINS |
| ISSN: | 1048-891X |
| DOI: | 10.1111/j.1048-891x.2004.014216.x |
| Popis: | Downregulation of major histocompatibility complex (MHC) class I molecules in cervix cancer has been proposed as a mechanism for cancer cells to escape immunodetection. By means of light microscopic immunohistochemistry, it has been shown that in 20–70% of cervix cancers MHC class I is downregulated. We have reinvestigated this phenomenon by quantitative immunogold analysis of MHC class I labeling on the plasma membrane of cervix epithelial cells in ten human squamous cancers and ten normal human cervices. We have not found a statistically significant difference in MHC class I expression between normal and cancer cells. The difference with published light microscopic data probably reflects the higher morphologic resolution and quantifiable immunoreactivity of the immunoelectron microscopy. |
| Databáze: | OpenAIRE |
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