A new series of thiosemicarbazone‐based anti‐inflammatory agents exerting their action through cyclooxygenase inhibition
| Autor: | Mehlika D. Altıntop, Belgin Sever, Gülşen Akalın Çiftçi, İpek Ertorun, Özkan Alataş, Ahmet Özdemir |
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| Rok vydání: | 2022 |
| Předmět: |
Thiosemicarbazones
Cyclooxygenase 2 Inhibitors Molecular Structure Anti-Inflammatory Agents Non-Steroidal Anti-Inflammatory Agents Pharmaceutical Science Antioxidants Molecular Docking Simulation Mice Structure-Activity Relationship Cyclooxygenase 2 Drug Discovery Cyclooxygenase 1 Animals Cyclooxygenase Inhibitors Ethers |
| Zdroj: | Archiv der Pharmazie. 355:2200136 |
| ISSN: | 1521-4184 0365-6233 |
| DOI: | 10.1002/ardp.202200136 |
| Popis: | In an endeavor to identify potent anti-inflammatory agents, new thiosemicarbazones (TSCs) incorporated into a diaryl ether framework (2a-2l) were prepared and screened for their in vitro inhibitory effects on cyclooxygenases (COXs). 4-[4-(Piperidin-1-ylsulfonyl)phenyl]-1-[4-(4-cyanophenoxy)benzylidene]thiosemicarbazide (2c) was the most potent and selective COX-1 inhibitor in this series, with an IC |
| Databáze: | OpenAIRE |
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