Hyper-connectivity of the thalamus during early stages following mild traumatic brain injury
| Autor: | Elijah O. George, Steven Roys, Rao P. Gullapalli, Chandler Sours, Jiachen Zhuo |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Traumatic brain injury Proton Magnetic Resonance Spectroscopy Rest Cognitive Neuroscience Population Neuropsychological Tests Audiology Article Behavioral Neuroscience Cellular and Molecular Neuroscience Atlases as Topic Cognition Thalamus Neural Pathways medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Neuropsychological assessment Effects of sleep deprivation on cognitive performance education Default mode network Brain Mapping education.field_of_study Resting state fMRI medicine.diagnostic_test Neuropsychology medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Neurology Brain Injuries Posterior cingulate Acute Disease Female Neurology (clinical) Psychology Neuroscience |
| Zdroj: | Brain Imaging and Behavior. 9:550-563 |
| ISSN: | 1931-7565 1931-7557 |
| Popis: | The thalamo-cortical resting state functional connectivity of seven sub-thalamic regions were examined in a prospectively recruited population of 77 acute mild TBI (mTBI) patients within the first 10 days (mean 6 ± 3 days) of injury and 35 neurologically intact control subjects using the Oxford thalamic connectivity atlas. Neuropsychological assessments were conducted using the Automated Neuropsychological Assessment Metrics (ANAM). A subset of participants received a magentic resonance spectroscopy (MRS) exam to determine metabolite concentrations in the thalamus and the posterior cingulate cortex. Results show that patients performed worse than the control group on various subtests of ANAM and the weighted throughput score, suggesting reduced cognitive performance at this early stage of injury. Both voxel and region of interest based analysis of the resting state fMRI data demonstrated that acute mTBI patients have increased functional connectivity between the various sub-thalamic regions and cortical regions associated with sensory processing and the default mode network (DMN). In addition, a significant reduction in NAA/Cr was observed in the thalamus in the mTBI patients. Furthermore, an increase in Cho/Cr ratio specific to mTBI patients with self-reported sensory symptoms was observed compared to those without self-reported sensory symptoms. These results provide novel insights into the neural mechanisms of the brain state related to internal rumination and arousal, which have implications for new interventions for mTBI patients with persistent symptoms. Furthermore, an understanding of heightened sensitivity to sensory related inputs during early stages of injury may facilitate enhanced prediction of safe return to work. |
| Databáze: | OpenAIRE |
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