Geographical location influences the composition of the gut microbiota in wild house mice (Mus musculus domesticus) at a fine spatial scale

Autor: Jonathan Fenn, Stuart Young, Andrew D. C. MacColl, Ann Lowe, Alexandre B. de Menezes, Benoit Poulin, Janette E. Bradley, Sarah Goertz, Richard J. Birtles, Christopher H. Taylor
Přispěvatelé: Natural Environment Research Council, Biotechnology and Biological Sciences Research Council
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
0106 biological sciences
0301 basic medicine
Topography
Rodent
Gut flora
Pathology and Laboratory Medicine
01 natural sciences
House mouse
Mice
Medicine and Health Sciences
Geographical location
Islands
Mammals
Mus musculus domesticus
education.field_of_study
Multidisciplinary
Ecology
Geography
biology
wild house mice
Eukaryota
Genomics
Trophic Interactions
Bacterial Pathogens
Shannon Index
Community Ecology
Medical Microbiology
Vertebrates
Medicine
Female
Pathogens
Research Article
Ecological Metrics
Science
education
Population
Zoology
Microbial Genomics
Environment
Microbiology
Rodents
010603 evolutionary biology
digestive system
03 medical and health sciences
biology.animal
Genetics
Parasitic Diseases
Animals
Microbiome
Microbial Pathogens
Ecosystem
Clostridium
Landforms
Bacteria
gut microbiota
Host (biology)
Gut Bacteria
Ecology and Environmental Sciences
Organisms
Biology and Life Sciences
Geomorphology
Species Diversity
biology.organism_classification
Gastrointestinal Microbiome
030104 developmental biology
Scotland
Amniotes
Earth Sciences
Spatial ecology
House mice
Zdroj: PLoS ONE, Vol 14, Iss 9, p e0222501 (2019)
PLoS ONE
ISSN: 1932-6203
Popis: The composition of the mammalian gut microbiota can be influenced by a multitude of environmental variables such as diet and infections. Studies investigating the effect of these variables on gut microbiota composition often sample across multiple separate populations and habitat types. In this study we explore how variation in the gut microbiota of the house mouse (Mus musculus domesticus) on the Isle of May, a small island off the east coast of Scotland, is associated with environmental and biological factors. Our study focuses on the effects of environmental variables, specifically trapping location and surrounding vegetation, as well as the host variables sex, age, body weight and endoparasite infection, on the gut microbiota composition across a fine spatial scale in a freely interbreeding population. We found that differences in gut microbiota composition were significantly associated with the trapping location of the host, even across this small spatial scale. Sex of the host showed a weak association with microbiota composition. Whilst sex and location could be identified as playing an important role in the compositional variation of the gut microbiota, 75% of the variation remains unexplained. Whereas other rodent studies have found associations between gut microbiota composition and age of the host or parasite infections, the present study could not clearly establish these associations. We conclude that fine spatial scales are important when considering gut microbiota composition and investigating differences among individuals. This work was supported by The Natural Environment Research Council (NERC) [grant number NE/L002604/1] as part of the Envision Doctoral Training Programme studentship (URL: https://nerc.ukri.org/) which was awarded to SG. This work was also supported by the Biotechnology and Biological Sciences Research Council [grant number BB/J014508/1], a Doctoral Training Programme studentship (URL: https://bbsrc.ukri.org/) awarded to SY and JF. The funders did not play any role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. peer-reviewed
Databáze: OpenAIRE
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