Chronic inflammation caused by lymphotoxin is lymphoid neogenesis
| Autor: | A Campos-Neto, Alexander Kratz, Nancy H. Ruddle, M S Hanson |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Lymphotoxin alpha
Lymphoid Tissue Recombinant Fusion Proteins Transgene Immunology High endothelial venules Mice Transgenic Inflammation Biology Kidney Islets of Langerhans Mice Antigen Antigens CD Cell Movement medicine Animals Insulin Immunology and Allergy Promoter Regions Genetic Lymphotoxin-alpha B cell Nephritis Proteins Articles Flow Cytometry Mice Mutant Strains DNA-Binding Proteins Lymphotoxin Lymphatic system medicine.anatomical_structure Pancreatitis Chronic Disease Leukocytes Mononuclear medicine.symptom |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| Popis: | In presenting a unifying concept for chronic inflammation and lymphoid organogenesis, we suggest that lymphotoxin's (LT, LT-alpha, TNF-beta) crucial role in these processes is pivotal and similar. Chronic inflammatory lesions that developed in the kidney and pancreas at the sites of transgene expression in rat insulin promoter-LT (RIP-LT) mice resembled lymph nodes with regard to cellular composition (T cells, B cells, plasma cells, and antigen-presenting cells), delineated T and B cell areas, primary and secondary follicles, characteristic morphologic and antigenic (ICAM-1, VCAM-1, MAdCAM-1, and PNAd) features of high endothelial venules, and ability to respond to antigen and undergo Ig class switching when obtained from mice immunized with SRBC. The vascular changes, with the exception of PNAd, appear to be the direct consequence of transgene derived LT expression, as they were also observed in RIP-LT mice lacking mature T and B cells. These data show that LT-induced chronic inflammation has the characteristics of organized lymphoid tissue. |
| Databáze: | OpenAIRE |
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