Kiwicha (Amaranthus caudatus L.) protein hydrolysates reduce intestinal inflammation by modulating the NLRP3 inflammasome pathway
| Autor: | Alicia Martinez-Lopez, Fernando Rivero-Pino, Alvaro Villanueva, Rocio Toscano, Elena Grao-Cruces, Elvira Marquez-Paradas, Maria E. Martin, Sergio Montserrat-de la Paz, Maria C. Millan-Linares |
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| Přispěvatelé: | Junta de Andalucía |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Popis: | 4 Figuras.-- 2 Tablas The increase in the world population along with new policies aimed at a more sustainable world has led to the need of searching for new food sources, which are environmentally friendly, implying healthy and nutritious diets. This study explored the biological activity of two kiwicha (Amaranthus caudatus L.) protein hydrolysates obtained with the aid of Bioprotease LA-660 regarding their anti-inflammatory response at the intestinal level, employing the CACO-2 cell line. The results obtained showed that the in vitro administration of these hydrolysates decreased the expression of proinflammatory cytokines, increased the expression of anti-inflammatory cytokines, and decreased the gene expression of the major components of inflammasomes in the intestinal CACO-2 cell model. To the best of our knowledge, this is the first study involving the evaluation of the anti-inflammatory activity of kiwicha hydrolysates at the intestinal level, employing the CACO-2 cell model and its ultrastructural characterization using scanning electron microscopy. We conclude that the Amaranthus caudatus hydrolysates are a valuable source of active peptides that take part as functional ingredients in food and nutraceutical preparations. This study was supported by a grant from the Andalusian Government (2021/CTS-1074). Rocio Toscano has the benefit of a “Margarita Salas” postdoctoral grant from the Recovery, Transformation and Resilience Plan (Next Generation EU). Elena Grao-Cruces has the benefit of a doctoral fellowship (BES-2012-056104) from the Andalusian Government. Maria C. Millan-Linares acknowledges the financial grant US-1381492 supported by Andalusian Plan for Research, Development, and Innovation 2020 from the European Regional Development Fund (ERDF). |
| Databáze: | OpenAIRE |
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