Absorption, Pharmacokinetics, and Safety of Triclosan after Dermal Administration
| Autor: | Christian Queckenberg, Oxana Doroshyenko, Bertil Wachall, Dorota Tomalik-Scharte, Jürgen Meins, Uwe Fuhr, Bärbel Bastian, Mona Abdel-Tawab |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Pharmacology No-Observed-Adverse-Effect Level Antiinfective agent No-observed-adverse-effect level Chemistry Administration Topical Skin Absorption Absorption (skin) Urine Triclosan Ointments Excretion chemistry.chemical_compound Infectious Diseases Pharmacokinetics Toxicity Anti-Infective Agents Local Humans Female Pharmacology (medical) |
| Zdroj: | Web of Science |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | We evaluated the pharmacokinetics and safety of the antimicrobial agent triclosan after dermal application of a 2% triclosan-containing cream to six volunteers. Percutaneous absorption calculated from urinary excretion was 5.9% ± 2.1% of the dose (mean ± standard deviation). The amount absorbed suggests that daily application of a standard adult dose would result in a systemic exposure 890 times lower than the relevant no-observed-adverse-effect level. Triclosan can be considered safe for use in hydrophobic creams. |
| Databáze: | OpenAIRE |
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