ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7
| Autor: | Neeltje van Doremalen, Claude Kwe Yinda, Teresa Lambe, Craig Martens, Danielle R. Adney, Greg Saturday, Myndi G. Holbrook, Kent D. Barbian, Brian J. Smith, Sarah C. Gilbert, Robert J. Fischer, Emmie de Wit, Stacy M. Ricklefs, Brandi N. Williamson, Sarah L. Anzick, Vincent J. Munster, Jonathan E Schulz, Julia R Port, Tina Thomas, Dan Long |
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| Rok vydání: | 2021 |
| Předmět: |
COVID-19 Vaccines
Live attenuated vaccines Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Science General Physics and Astronomy Hamster Antibodies Viral General Biochemistry Genetics and Molecular Biology Article ChAdOx1 nCoV-19 medicine Virus-neutralizing Antibody Animals Pulmonary pathology skin and connective tissue diseases Lung Administration Intranasal Subgenomic mRNA Vaccines Multidisciplinary biology Mesocricetus business.industry SARS-CoV-2 fungi Vaccination COVID-19 General Chemistry biology.organism_classification medicine.disease Vaccine efficacy Virology Antibodies Neutralizing body regions Titer Amino Acid Substitution Spike Glycoprotein Coronavirus Female Pathogens business Pneumonia (non-human) |
| Zdroj: | Nature Communications bioRxiv article-version (status) pre article-version (number) 2 Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021) |
| Popis: | We investigated ChAdOx1 nCoV-19 (AZD1222) vaccine efficacy against SARS-CoV-2 variants of concern (VOCs) B.1.1.7 and B.1.351 in Syrian hamsters. We previously showed protection against SARS-CoV-2 disease and pneumonia in hamsters vaccinated with a single dose of ChAdOx1 nCoV-19. Here, we observe a 9.5-fold reduction of virus neutralizing antibody titer in vaccinated hamster sera against B.1.351 compared to B.1.1.7. Vaccinated hamsters challenged with B.1.1.7 or B.1.351 do not lose weight compared to control animals. In contrast to control animals, the lungs of vaccinated animals do not show any gross lesions. Minimal to no viral subgenomic RNA (sgRNA) and no infectious virus can be detected in lungs of vaccinated animals. Histopathological evaluation shows extensive pulmonary pathology caused by B.1.1.7 or B.1.351 replication in the control animals, but none in the vaccinated animals. These data demonstrate the effectiveness of the ChAdOx1 nCoV-19 vaccine against clinical disease caused by B.1.1.7 or B.1.351 VOCs. Emerging SARS-CoV-2 variants raise concerns about vaccine effectiveness. Here, the authors show that the ChAdOx1 nCoV-19 (AZD1222) vaccine protects Syrian hamsters from pulmonary infection and disease after infection with SARS-CoV-2 B.1.351 or B.1.1.7 variants. |
| Databáze: | OpenAIRE |
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