Benzoylphosphonate-Based Photoactive Phosphopeptide Mimetics for Modulation of Protein Tyrosine Phosphatases and Highly Specific Labeling of SH2 Domains
| Autor: | Samuel Beligny, André Horatscheck, Jutta Ortwein, Stefan Wagner, Michael Lisurek, Boo Geun Kim, Anja Schütz, Jörg Rademann |
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| Rok vydání: | 2012 |
| Předmět: |
Phosphopeptides
Binding Sites Light Photoaffinity labeling biology Phosphopeptide Chemistry Affinity label Affinity Labels General Chemistry Protein tyrosine phosphatase SH2 domain Benzoates Catalysis Protein Structure Tertiary src Homology Domains Protein structure Biochemistry Proteome biology.protein Humans Computer Simulation Propionates Protein Tyrosine Phosphatases Binding site |
| Zdroj: | Angewandte Chemie International Edition. 51:9441-9447 |
| ISSN: | 1433-7851 |
| Popis: | A light switch for phosphotyrosine- recognizing proteins: Irradiation of the bioisosteric benzoylphosphonate suffices to "turn off" the activity of target proteins and to label them covalently. Photoactive bioisosters may find applications in functional cell biology, bioanalytics, and proteome research. |
| Databáze: | OpenAIRE |
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