Myocardial Hypertrophy and the Maturation of Fatty Acid Oxidation in the Newborn Human Heart
| Autor: | Ivan M. Rebeyka, Michael A Yatscoff, Gary D. Lopaschuk, Rachel Greenwood, Trish Lukat, Jagdip S. Jaswal, Donna L. Beker, Meghan R Grant |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Aging medicine.medical_specialty Carboxy-Lyases Heart Ventricles AMP-Activated Protein Kinases Biology Muscle hypertrophy chemistry.chemical_compound AMP-activated protein kinase Internal medicine medicine Animals Humans Phosphorylation Beta oxidation chemistry.chemical_classification Myocardium Fatty Acids Infant Newborn Acetyl-CoA carboxylase Infant AMPK Hypertrophy Malonyl-CoA decarboxylase Malonyl Coenzyme A Endocrinology Malonyl-CoA Enzyme chemistry Pediatrics Perinatology and Child Health biology.protein Female Oxidation-Reduction Acetyl-CoA Carboxylase |
| Zdroj: | Pediatric Research. 64:643-647 |
| ISSN: | 1530-0447 0031-3998 |
| Popis: | After birth dramatic decreases in cardiac malonyl CoA levels result in the rapid maturation of fatty acid oxidation. We have previously demonstrated that the decrease in malonyl CoA is due to increased activity of malonyl CoA decarboxylase (MCD), and decreased activity of acetyl CoA carboxylase (ACC), enzymes which degrade and synthesize malonyl CoA, respectively. Decreased ACC activity corresponds to an increase in the activity of 5'-AMP activated protein kinase (AMPK), which phosphorylates and inhibits ACC. These alterations are delayed by myocardial hypertrophy. As rates of fatty acid oxidation can influence the ability of the heart to withstand an ischemic insult, we examined the expression of MCD, ACC, and AMPK in the newborn human heart. Ventricular biopsies were obtained from infants undergoing cardiac surgery. Immunoblot analysis showed a positive correlation between MCD expression and age. In contrast, a negative correlation in both ACC and AMPK expression and age was observed. All ventricular samples displayed some degree of hypertrophy, however, no differences in enzyme expression were found between moderate and severe hypertrophy. This indicates that increased expression of MCD, and the decreased expression of ACC and AMPK are important regulators of the maturation of fatty acid oxidation in the newborn human heart. |
| Databáze: | OpenAIRE |
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