Metformin and ageing: improving ageing outcomes beyond glycaemic control
Autor: | Leonardo Tamariz, Willy Marcos Valencia, Ana Palacio, Hermes Florez |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Blood Glucose medicine.medical_specialty Aging endocrine system diseases Endocrinology Diabetes and Metabolism Population 030209 endocrinology & metabolism Article 03 medical and health sciences 0302 clinical medicine Internal medicine Internal Medicine Medicine Animals Humans Hypoglycemic Agents Intensive care medicine education Beneficial effects education.field_of_study Human studies business.industry nutritional and metabolic diseases Metformin Clinical trial 030104 developmental biology Endocrinology Ageing Observational study Human research business medicine.drug |
Zdroj: | Diabetologia. 60(9) |
ISSN: | 1432-0428 |
Popis: | In a world where the population is ageing, there is growing interest and demand for research evaluating strategies that address the ageing process. After 60 years of successful use of metformin in our pharmaceutical armamentarium, we are learning that, beyond improving glycaemic control, metformin may have additional mechanisms and pathways of action that need further study. Although, metformin’s effect on clinical ageing outcomes may still be considered speculative, the findings from studies into cellular and animal models and from observational and pilot human studies support the existence of beneficial effects on ageing. At present, progress for human research, using randomised clinical trials to evaluate metformin’s clinical impact, has just started. Here, we present a review on the ageing process and the mechanisms involved, and the role that metformin may have to counter these. We go on to discuss the upcoming large randomised clinical trials that may provide insight on the use of metformin for ageing outcomes beyond glycaemic control. |
Databáze: | OpenAIRE |
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