A Multicentric Randomised Study of Alpha 2b Interferon (IFN) and Hydroxyurea (HU) with or without Cytosine-Arabinoside (Ara-c) in Previously Untreated Patients with Ph+ Chronic Myelocytic Leukemia (CML): Preliminary Cytogenetic Results
| Autor: | Herve Tilly, B. Christian, Philippe Cassasus, H. Rochant, Francis Bauters, Pierre-Yves Le Prise, Jean-Francois Abgrall, Gerard Dine, Jean-Luc Harousseau, F. Guilhot, J. P. Lamagnere, Pauline Brice, Brigitte Duclos, Norbert Ifrahy, Agnès Guerci, Joseph Tanzer |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent Alpha (ethology) Interferon alpha-2 chemistry.chemical_compound Maintenance therapy Interferon Leukemia Myelogenous Chronic BCR-ABL Positive Internal medicine Humans Immunologic Factors Medicine Aged Hematology business.industry Remission Induction Cytarabine Cytogenetics Interferon-alpha Middle Aged Combined Modality Therapy Recombinant Proteins Treatment Outcome Oncology chemistry Leukemia Myeloid Chronic-Phase Immunology Female Myelocytic leukemia France business Cytosine medicine.drug |
| Zdroj: | Leukemia & Lymphoma. 11:181-183 |
| ISSN: | 1029-2403 1042-8194 |
| DOI: | 10.3109/10428199309047883 |
| Popis: | The CML 88 study was designed to evaluate the efficacy of maintenance therapy in a multicentric randomised protocol using IFN combined with low-dose Ara-C versus IFN alone, following an induction with IFN + HU. Between April 1988 and February 1991, 237 patients from 36 French Hematology Centres were entered in the study. Preliminary cytogenetic results show a slightly higher, although not statistically significant, proportion of major chromosomal responses, including complete cytogenetic remissions, in the IFN + Ara C arm. |
| Databáze: | OpenAIRE |
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