Anatomical and hemodynamic evaluations of the heart and pulmonary arterial pressure in healthy children residing at high altitude in China
| Autor: | Yue-Hong Cai, Hai-Ying Qi, Ru-Yan Ma, Mei-Ying Wang, Shu-Ping Li, Shu Mai, Li-Xia Jiang, Hai-Ning Liu, Mei Ge, Su-Ya Xu, Jia Li, Hong Chen |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Cardiac function curve
medicine.medical_specialty Cardiac output lcsh:Diseases of the circulatory (Cardiovascular) system Cardiac & Cardiovascular Systems Cardiac morphology Diastole Hemodynamics Article Altitude Right ventricular hypertrophy Internal medicine medicine Healthy children Cardiopulmonary disease business.industry Cardiac function Effects of high altitude on humans medicine.disease Pulmonary arterial pressure lcsh:RC666-701 Cardiology Cardiology and Cardiovascular Medicine business Tibetan |
| Zdroj: | International Journal of Cardiology: Heart & Vasculature, Vol 7, Iss C, Pp 158-164 (2015) International Journal of Cardiology. Heart & Vasculature Scipedia Open Access Scipedia SL |
| ISSN: | 2352-9067 |
| Popis: | Objectives: Altitude-hypoxia induces pulmonary arterial hypertension and altered cardiac morphology and function, which is little known in healthy children at high altitude. We compared the cardiopulmonary measurements between the healthy children at 16 m and those at 3700 m in China and between the Hans and the Tibetans at 3700 m. Methods: Echocardiography was assessed in 477 children (15 day–14 years) including 220 at 16 m and 257 at 3700 m. The dimensions and wall thickness of the left- and right-sided heart, systolic and diastolic functions including cardiac output index (CI) were measured using standard methods. Mean pulmonary arterial pressure (mPAP) was estimated by the Doppler waveforms in the main pulmonary artery. Results: Compared to the 16 m-group, 3700 m-group had higher mPAP, increasing dilatation of the right heart, and slower decrease in right ventricular hypertrophy in 14 years (p 0.20). Systolic and diastolic functions of both ventricles were significantly reduced, but CI was higher (p 0.05). Conclusions: Children living at high altitude in China have significantly higher mPAP, dilated right heart and slower regression of right ventricular hypertrophy in the first 14 years of life. Systolic and diastolic functions of both ventricles were reduced with a paradoxically higher CI. There was no significant difference in these features between the Hans and the Tibetans. These values provide references for the care of healthy children and the sick ones with cardiopulmonary diseases at high altitude. |
| Databáze: | OpenAIRE |
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