Sub-acute toxicity study in female ICR mice following repetitive intramuscular injection of cervical cancer vaccines
| Autor: | Seung Min Oh, Jiwon Jung, Sujeong Kim, Kim Minju, Yong-Hoon Lee, Jae Sung Lee, Hye-Yeong Lee, Hee-Won Park, Jung-Min Lee, Duyeol Kim, Yu-Kyoung Oh, Young-Bong Kim, Kyoung-Baek Choi, Seol-Hee Moon |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Cervical cancer
business.industry Health Toxicology and Mutagenesis Repetitive intramuscular injection Subacute toxicity Public Health Environmental and Occupational Health Physiology Cervical cancer vaccine Body weight medicine.disease Toxicology Environmental sciences Immunology medicine Female ICR mice Original Article GE1-350 Intramuscular injection business Icr mice Organ weight |
| Zdroj: | Environmental Health and Toxicology, Vol 29 (2014) Environmental Health and Toxicology |
| ISSN: | 2233-6567 |
| Popis: | Objectives : The sub-acute toxic effects following repetitive intramuscular injection of two cervical cancer vaccines newly developed against human papillomaviruse (HPV)16/58/18 and HPV16 were investigated in female ICR (CrljOri: CD1) mice, and the no-observedadverse-effect-level (NOAEL) of the cervical cancer vaccines was estimated. Methods : Female ICR mice (n=15 in each group) were exposed to a 1:1 mixture of two cervical cancer vaccines by repetitive intramuscular injection (once a week, 5 times) for 5 weeks. Mortality, body weight, organ weight, hematological/biochemical parameters, and histopathological effects were examined at different concentrations (0, 1×10 8 , 5×10 8 , and 2.5×10 9 copies/animal) of the cervical cancer vaccines. Results : The cervical cancer vaccines did not show toxic responses for body weight, absolute/relative organ weight, hematological/biochemical parameters, or histopathological parameters. Conclusions Female ICR mice exposed to vaccines for cervical cancer did not show any toxic response. We suggest that a NOAEL of the vaccine following repetitive intramuscular injection for 5 weeks is >2.5×10 9 copies/animal. |
| Databáze: | OpenAIRE |
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