Genetic variants of tumor necrosis factor-α -308G/A (rs1800629) but not Toll-interacting proteins or vitamin D receptor genes enhances susceptibility and severity of malaria infection
| Autor: | Olusola Ojurongbe, Catherine O. Falade, Tara J Snyder, Iman Farid, Roland I. Funwei, Yi Li, Bolaji N. Thomas, Najihah Aziz |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male Genotype Immunology Calcitriol receptor Polymorphism Single Nucleotide 03 medical and health sciences Immune system Gene Frequency parasitic diseases Genetics Humans Genetic Predisposition to Disease Allele Malaria Falciparum Africa South of the Sahara biology Tumor Necrosis Factor-alpha TOLLIP Haplotype Intracellular Signaling Peptides and Proteins Genetic Variation Plasmodium falciparum Middle Aged biology.organism_classification Malaria 030104 developmental biology Haplotypes Receptors Calcitriol Tumor necrosis factor alpha Female |
| Zdroj: | Immunogenetics. 70(2) |
| ISSN: | 1432-1211 |
| Popis: | Susceptibility to malaria infection has been associated with host genetic polymorphisms that differs between groups. We hypothesize that Toll-interacting proteins (TOLLIP), vitamin D receptor (VDR) and tumor necrosis factor-α (TNF) genes are significant contributors to susceptibility and disease severity in Plasmodium falciparum (Pf) infection. Our aim is to explore the genomic diversity and haplotype frequency of these genes, as well as extrapolate possible association with markers of severity, between malaria-infected and healthy controls. Genomic DNA samples extracted from the blood of 107 malaria-infected patients and 190 uninfected controls were analyzed, with no difference in genotypic or allelic frequencies of TOLLIP and VDR polymorphisms. However, a significant difference in the genotypic (p = 2.20E-16) and allelic frequencies (p = 2.20E-16) of the TNF-α (snp rs1800629) polymorphism was found. The preponderance of the mutant variant among the malaria-infected show a possible impaired capacity to mount an effective immune response, potentially confirmed by our association results. This result calls for analysis of clearly delineated uncomplicated versus severe disease groups, including serum assays, providing a basis to conclude that susceptibility to malaria infection and potential contribution to disease severity is significantly associated with polymorphisms of the tumor necrosis factor-α but not TOLLIP or VDR genes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink