The association between vitamin D deficiency and hospitalization outcomes in pediatric patients with sickle cell disease
| Autor: | Jolanta Kulpa, Revathy Sundarum, Brande Brown, Sara Zarzoso-Fernandez, Levon Agdere, Deepak Choudhary, Kathleen Long |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Adolescent Population Pain Disease Anemia Sickle Cell vitamin D deficiency 03 medical and health sciences 0302 clinical medicine Patient Admission Chart review Internal medicine Pain crisis medicine Vitamin D and neurology Humans Pain Management In patient education Child Molecular Biology Retrospective Studies education.field_of_study business.industry Chronic pain Infant Cell Biology Hematology medicine.disease Vitamin D Deficiency 030104 developmental biology Child Preschool Molecular Medicine Female business Emergency Service Hospital 030215 immunology Follow-Up Studies |
| Zdroj: | Blood cells, moleculesdiseases. 82 |
| ISSN: | 1096-0961 |
| Popis: | While there is a known association between low vitamin D levels and increased chronic pain in patients with Sickle Cell Disease (SCD), there are no reported studies evaluating the relationship of vitamin D levels and hospitalization outcomes in this population. The aim of this study was to assess this relationship with hospitalization outcomes defined as the number of emergency room (ER) visits, hospital admissions for pain crisis, and length of hospital stay.A retrospective chart review of all pediatric patients with SCD (1-21 years old) was performed from January 2015 to January 2016 in an urban-based hospital setting (n = 134). Those with at least one reported Vitamin D level who maintained follow up during the time studied were enrolled (n = 90). Patient hospitalizations rates were compared between vitamin D deficiency (20 ng/ml) and sufficiency (20 ng/ml).Patients with both SCD and vitamin D deficiency were more likely to have at least one Emergency Room visit (p 0.01), at least one admission for pain crisis (p 0.01), and a longer length of admission (p 0.0001) when compared to patients with SCD and sufficient vitamin D levels.There is a significant association between vitamin D levels of20 ng/ml and the number of ER visits, hospital admissions for pain crisis, and length of stay in patients with SCD. Further research is required to assess if correcting vitamin D levels may improve hospitalization outcomes in this population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect