A composite hydrogel for brain tissue phantoms
| Autor: | Stefano Galvan, F. Rodriguez y Baena, F Manieri, Daniele Dini, Antonio Forte |
|---|---|
| Přispěvatelé: | Commission of the European Communities, Engineering & Physical Science Research Council (E, Engineering & Physical Science Research Council (EPSRC) |
| Rok vydání: | 2016 |
| Předmět: |
Materials science
Brain shift Mechanical Engineering 0206 medical engineering Composite number Materials Engineering 02 engineering and technology Brain tissue 021001 nanoscience & nanotechnology Biocompatible material 020601 biomedical engineering Computer aided surgery Materials Science(all) Mechanics of Materials Self-healing hydrogels lcsh:TA401-492 book.journal lcsh:Materials of engineering and construction. Mechanics of materials General Materials Science 0210 nano-technology Materials book Engineered tissue Tissue phantom Biomedical engineering |
| Zdroj: | Materials & Design, Vol 112, Iss, Pp 227-238 (2016) |
| ISSN: | 0264-1275 |
| DOI: | 10.1016/j.matdes.2016.09.063 |
| Popis: | Synthetic phantoms are valuable tools for training, research and development in traditional and computer aided surgery, but complex organs, such as the brain, are difficult to replicate. Here, we present the development of a new composite hydrogel capable of mimicking the mechanical response of brain tissue under loading. Our results demonstrate how the combination of two different hydrogels, whose synergistic interaction results in a highly tunable blend, produces a hybrid material that closely matches the strongly dynamic and non-linear response of brain tissue. The new synthetic material is inexpensive, simple to prepare, and its constitutive components are both widely available and biocompatible. Our investigation of the properties of this engineered tissue, using both small scale testing and life-sized brain phantoms, shows that it is suitable for reproducing the brain shift phenomenon and brain tissue response to indentation and palpation. Keywords: Composite hydrogel, Tissue phantom, Brain tissue, Mechanical characterisation, Surrogate material, Mimicking |
| Databáze: | OpenAIRE |
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