Peri-partum reference ranges for ROTEM (R) thromboelastometry

Autor: Hubertina C.J. Scheepers, N.M. de Lange, Martina Porath, Luc J.M. Smits, Antoinette C. Bolte, L.E. van Rheenen-Flach, L. Mooyman, Mallory Woiski, Marcus D. Lancé, Yvonne M. C. Henskens, E. C. M. van Pampus
Přispěvatelé: Obstetrics and gynaecology, ICaR - Ischemia and repair, RS: CAPHRI School for Public Health and Primary Care, RS: CARIM - R1 - Thrombosis and haemostasis, RS: GROW - Developmental Biology, Interne Geneeskunde, Epidemiologie, Obstetrie & Gynaecologie, Anesthesiologie, MUMC+: DA CDL Algemeen (9), Intensive Care, Biochemie, RS: CAPHRI - Clinical epidemiology, RS: GROW - R4 - Reproductive and Perinatal Medicine
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Adult
medicine.medical_specialty
Vascular damage Radboud Institute for Health Sciences [Radboudumc 16]
POSTPARTUM HEMORRHAGE
Other Research Radboud Institute for Molecular Life Sciences [Radboudumc 0]
COAGULATION TESTS
DELIVERY
blood
medicine
Coagulation testing
Peripartum Period
Humans
HEMOSTASIS
blood
coagulation
coagulation
Blood Coagulation
Blood coagulation test
Monitoring
Physiologic
Netherlands
Clotting factor
medicine.diagnostic_test
business.industry
Other Research Radboud Institute for Health Sciences [Radboudumc 0]
thromboelastography
reference values
Thromboelastography
Surgery
Thrombelastography
Thromboelastometry
Anesthesiology and Pain Medicine
ROTATION THROMBOELASTOMETRY
PREGNANCY
Coagulation
Clotting time
Hemostasis
haemostasis
CLOT FIRMNESS
Female
REFERENCE INTERVALS
Blood Coagulation Tests
MAJOR TRAUMA
post-partum haemorrhage
Nuclear medicine
business
CARDIAC-SURGERY
Zdroj: de Lange, N, van Rheenen-Flach, L, Lance, M, Mooyman, L, Woiski, M, van Pampus, E, Porath, M, Bolte, A C, Smits, L, Henskens, Y & Scheepers, H 2014, ' Peri-partum reference ranges for ROTEM (R) thromboelastometry ', British Journal of Anaesthesia, vol. 112, no. 5, pp. 852-859 . https://doi.org/10.1093/bja/aet480
British Journal of Anaesthesia, 112(5), 852-859. Oxford University Press
British Journal of Anaesthesia, 112, 5, pp. 852-9
British Journal of Anaesthesia, 112, 852-9
British Journal of Anaesthesia, 112(5), 852-859. ELSEVIER SCI LTD
ISSN: 1471-6771
0007-0912
DOI: 10.1093/bja/aet480
Popis: Item does not contain fulltext BACKGROUND: Post-partum haemorrhage (PPH) causes rapidly developing deficiencies in clotting factors and contributes to substantial maternal morbidity and mortality. Rotational thromboelastometry (ROTEM((R))) is increasingly used as a point of care coagulation monitoring device in patients with massive haemorrhage; however, there are limited data on reference ranges in the peri-partum period. These are required due to the haemostatic changes in pregnancy. METHODS: In a Dutch multi-centre trial, 161 subjects were included; blood samples were obtained during labour (T1) and within 1 h of delivery (T2). Reference ranges of ROTEM((R)) INTEM, EXTEM, FIBTEM, and APTEM were set and correlation with laboratory results was investigated using the guidelines of the International Federation of Clinical Chemistry. RESULTS: Reference ranges were obtained for clotting time (CT), clot formation time (CFT), alpha-angle, clot firmness at 10 and 20 min (A10, A20), maximum clot firmness (MCF), and maximum lysis (ML). These were comparable from centre to centre, and between T1 and T2. Reference ranges T1: EXTEM: CT 31-63 s, CFT 41-120 s, and MCF 42-78 mm. INTEM: CT 109-225 s, CFT 40-103, and MCF 63-78 mm. FIBTEM: CT 31-79 s and MCF 13-45 mm. APTEM: CT 33-62 s, CFT 42-118, and MCF 61-79 mm. CONCLUSIONS: Reference values for ROTEM((R)) parameters are reported. The previously published correlation between FIBTEM parameters and plasma fibrinogen levels by the Clauss method is confirmed. Further research is needed to define threshold values for haemostatic therapy in the course of PPH. Clinical trial registration NTR 2515 (http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2515).
Databáze: OpenAIRE
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