Clinical and angiographic correlation of high-sensitivity C-reactive protein with acute ST elevation myocardial infarction
| Autor: | Shams Tabrez, Nanjappa C. Manjunath, Syed Tanveer, Shaheena Banu, Nasimudeen R. Jabir, Mohd Shahnawaz Khan, Ghulam Md Ashraf |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Acute coronary syndrome 030204 cardiovascular system & hematology Coronary artery disease 03 medical and health sciences 0302 clinical medicine Reperfusion therapy Immunology and Microbiology (miscellaneous) Internal medicine Diabetes mellitus medicine ST segment 030212 general & internal medicine Myocardial infarction biology business.industry ST elevation C-reactive protein General Medicine Articles medicine.disease biology.protein Cardiology business |
| Popis: | Vascular inflammation and associated ongoing inflammatory responses are considered as the critical culprits in the pathogenesis of acute atherothrombotic events such as acute coronary syndrome (ACS) and myocardial infarction (MI). ST segment elevation myocardial infarction (STEMI) is considered as one of the prominent clinical forms of ACS. Moreover, C-reactive protein (CRP) is an important acute phase prsotein, which may be estimated using high-sensitivity methods (hs-CRP), and its elevated level in body fluids reflects chronic inflammatory status. The circulating hs-CRP level has been proposed as a promising inflammatory marker of coronary artery disease (CAD). The present study investigated the correlation of hs-CRP level with clinical and angiographic features of STEMI, various other traditional risk factors, complications of myocardial infarction and angiographically significant CAD. Out of 190 patients with STEMI that were analyzed, the interval between symptom onset and reperfusion therapy (window period) varied from 0.5 to 24 h. The hs-CRP value was found to be higher in non-diabetic patients (0.61 mg/dl) compared with diabetic patients (0.87 mg/dl). Moreover, a significant correlation between hs-CRP and hs-troponin T was also recorded (P |
| Databáze: | OpenAIRE |
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