Links between Cognitive Status and Trace Element Levels in Hair for an Environmentally Exposed Population: A Case Study in the Surroundings of the Estarreja Industrial Area
| Autor: | Edgar Pinto, Amelia Reis, Maria Orquídia Neves, Manuela Inácio, Agostinho Almeida, Eduardo Ferreira da Silva, Pedro Dinis, Marina Cabral Pinto, Mário Simoes, Luisa Dinis, AlessanRSS Reis, Paula Moreira, Bianca Gerardo, Sandra Freitas |
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| Přispěvatelé: | Universidade de Aveiro, GeoBioTec, Universidade de Aveiro, Universidade de Coimbra [Coimbra], Marine and Environmental Sciences Centre [Portugal] (MARE), Instituto Universitário de Ciências Psicológicas, Sociais e da Vida (ISPA), ANR-11-LABX-0010,DRIIHM / IRDHEI,Dispositif de recherche interdisciplinaire sur les Interactions Hommes-Milieux(2011), Universidade do Minho |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Health Toxicology and Mutagenesis lcsh:Medicine trace elements 010501 environmental sciences 01 natural sciences Cognition 0302 clinical medicine Cognitive status Statistical analysis Cognitive impairment ComputingMilieux_MISCELLANEOUS Aged 80 and over education.field_of_study Industrial area 3. Good health Female mercury Exposed Population Population OHMi Estarreja Article 03 medical and health sciences Alzheimer Disease Memory Environmental health medicine Humans Industry Dementia Cognitive Dysfunction education Aged 0105 earth and related environmental sciences cognitive impairment Science & Technology Portugal business.industry lcsh:R Public Health Environmental and Occupational Health Trace element Environmental Exposure medicine.disease [SDE.ES]Environmental Sciences/Environmental and Society exposure [SDE.BE]Environmental Sciences/Biodiversity and Ecology Environmental Pollution business 030217 neurology & neurosurgery Hair |
| Zdroj: | International Journal of Environmental Research and Public Health Volume 16 Issue 22 International Journal of Environmental Research and Public Health, MDPI, 2019, 16 (22), pp.4560. ⟨10.3390/ijerph16224560⟩ International Journal of Environmental Research and Public Health, Vol 16, Iss 22, p 4560 (2019) Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph16224560 |
| Popis: | In the present study, trace elements (TE) levels were evaluated in scalp hair along the continuum from healthy subjects (HS) to patients suffering from subjective memory concerns (SMC), and/or mild cognitive impairment (MCI), and those with already installed dementia (DEM) in order to: (i) assess the effects of environmental and lifestyle factors on TE concentrations and (ii) evaluate the analyzed elements as possible diagnostic biomarkers for the disease. The study involved 79 mainly permanent residents, >55 years old, from the city of Estarreja (northern Portugal), a former industrial area. The health status of the participants was assessed by means of a complete socio-demographic questionnaire and through cognitive screening tests, namely the Mini-Mental State Examination (MMSE). The test scores were categorized and used in the statistical analysis. Hair samples were collected and analyzed by inductively coupled plasma-mass spectrometry (ICP-MS) ICP-MS for selected TE. Dementia appears to be associated with higher age, the female gender, lower education level, and longer residence time in the study area. In addition, most of the participants diagnosed with dementia frequently consume home-grown foodstuffs, some irrigated with contaminated well water. The calculation of the TE enrichment factors of soil samples collected in kitchen gardens/small farms in the vicinity of the Estarreja Chemical Complex (ECC) reinforces the degree of Hg soil contamination in the area, due to anthropogenic sources that can be a source for the population Hg exposure route among others. Mercury levels in hair differed significantly between the four individual groups (HS, SMC, MCI, and DEM), increasing from healthy to dementia participants. Improved diagnostic results can be obtained using hair TE signatures coupled with MMSE scores. This strategy may prove useful for predictive diagnosis in population screening for cognitive impairment. Funding for this research was provided by the Projects SFRH/BPD/71030/2010, Project UID/GEO/04035/2019 (GeoBioTec Research Centre) financed by FCT – Fundação para a Ciência e Tecnologia and by the Labex DRIIHM, Réseau des Observatoires Hommes-Millieux–Centre National de la Recherche Scientifique (ROHM–CNRS) and OHMI-Estarreja. We thank also the participants for taking part in this research and the local private institutions of social solidarity for their collaboration (Santa Casa Misericórdia de Estarreja, Associação Humanitária de Salreu, Centro Paroquial Social São Tomé de Canelas, Centro Paroquial Social Avanca, Fundação Cónego Filipe Figueiredo Beduído and Centro Paroquial de Pardilhó). The manuscript benefited from careful and constructive reviews by three anonymous reviewers. |
| Databáze: | OpenAIRE |
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