Long-term phosphorus restriction prevents corticomedullary nephrocalcinosis and sustains reproductive performance but delays bone mineralization in rats
| Autor: | A. C. Beynen, A. G. Lemmens, L. H. J. C. Danse, J.N.J.J. Mathot, J. Ritskes-Hoitinga, G. van Tintelen, G. W. Meijer |
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| Jazyk: | angličtina |
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty kidney Diet therapy Medicine (miscellaneous) chemistry.chemical_element Administration Oral Biology Calcium Mineralization (biology) reproduction Calcification Physiologic Internal medicine Lactation nephrocalcinosis medicine Animals Phosphorus deficiency Rats Wistar Human Nutrition & Health Nutrition and Dietetics Dose-Response Relationship Drug Body Weight Humane Voeding & Gezondheid Phosphorus medicine.disease rats Dose–response relationship medicine.anatomical_structure Endocrinology chemistry bone development Female Nephrocalcinosis Hypophosphatemia |
| Zdroj: | The Journal of Nutrition, 123(4), 754-763 The Journal of Nutrition 123 (1993) 4 |
| ISSN: | 0022-3166 |
| Popis: | In a long-term experiment with three successive generations of rats, the influence of dietary phosphorus restriction (2 instead of 4 g phosphorus/kg diet) on nephrocalcinosis, reproduction and bone mineralization was studied. Nephrocalcinosis in female rats, as based on kidney calcium concentration and histological examination, was prevented by phosphorus restriction. The low phosphorus diet caused reduced femur concentrations of magnesium, calcium and phosphorus in rats of the first and second generation aged 4 to 12 wk. The low phosphorus diet resulted in lower plasma phosphorus concentrations. In the kidneys of female rats, immediately after lactation, a higher degree of tubular hyperplasia was seen after the low phosphorus diet was fed. Reproductive performance was not affected by phosphorus restriction. We conclude that 0.2% phosphorus in the diet prevents nephrocalcinosis in female rats while it sustains reproduction but delays bone mineralization. |
| Databáze: | OpenAIRE |
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