Analysis of shared homozygosity regions in Saudi siblings with attention deficit hyperactivity disorder
Autor: | Dejene Abebe, Basma S. AlAbdulaziz, Faten M. Alnaemi, Eman A.A. Al Yemni, Jameela Shinwari, Nada Al Tassan, Mohammad Ghaziuddin, Bashayer R. Al Mubarak |
---|---|
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Adolescent Genetic Linkage Saudi Arabia Consanguinity homozygosity region 03 medical and health sciences 0302 clinical medicine consanguinity multiplex families Genetics medicine sib-pair analysis Attention deficit hyperactivity disorder Humans Family Genetic Predisposition to Disease Psychiatry Child Biological Psychiatry Genetics (clinical) business.industry Siblings Homozygote Original Articles Heritability medicine.disease Pedigree Psychiatry and Mental health 030104 developmental biology attention deficit hyperactivity disorder Attention Deficit Disorder with Hyperactivity Child Preschool Identification (biology) Female business 030217 neurology & neurosurgery Genome-Wide Association Study |
Zdroj: | Psychiatric Genetics |
ISSN: | 1473-5873 |
Popis: | Aim Genetic and clinical complexities are common features of most psychiatric illnesses that pose a major obstacle in risk-gene identification. Attention deficit hyperactivity disorder (ADHD) is the most prevalent child-onset psychiatric illness, with high heritability. Over the past decade, numerous genetic studies utilizing various approaches, such as genome-wide association, candidate-gene association, and linkage analysis, have identified a multitude of candidate loci/genes. However, such studies have yielded diverse findings that are rarely reproduced, indicating that other genetic determinants have not been discovered yet. In this study, we carried out sib-pair analysis on seven multiplex families with ADHD from Saudi Arabia. We aimed to identify the candidate chromosomal regions and genes linked to the disease. Patients and methods A total of 41 individuals from multiplex families were analyzed for shared regions of homozygosity. Genes within these regions were prioritized according to their potential relevance to ADHD. Results We identified multiple genomic regions spanning different chromosomes to be shared among affected members of each family; these included chromosomes 3, 5, 6, 7, 8, 9, 10, 13, 17, and 18. We also found specific regions on chromosomes 8 and 17 to be shared between affected individuals from more than one family. Among the genes present in the regions reported here were involved in neurotransmission (GRM3, SIGMAR1, CHAT, and SLC18A3) and members of the HLA gene family (HLA-A, HLA-DPA1, and MICC). Conclusion The candidate regions identified in this study highlight the genetic diversity of ADHD. Upon further investigation, these loci may reveal candidate genes that enclose variants associated with ADHD. Although most ADHD studies were conducted in other populations, our study provides insight from an understudied, ethnically interesting population. |
Databáze: | OpenAIRE |
Externí odkaz: |