Preclinical coronary endothelial dysfunction in Egyptian Behçet’s disease patients; Tc-99m sestamibi pharmacological Gated-SPECT, is it a useful screening tool?
| Autor: | Zeinab Nawito, Amr M. Amin |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Gated SPECT Behcet's disease Behçet’s Disease Single-photon emission computed tomography Subclinical vascular endothelial dysfunction medicine.disease Asymptomatic Dipyridamole Myocardial perfusion imaging Cardio-Behçet Rheumatology Internal medicine medicine Cardiology Endothelial dysfunction medicine.symptom business Gated-SPECT Subclinical infection medicine.drug |
| Zdroj: | The Egyptian Rheumatologist. (3):159-166 |
| ISSN: | 1110-1164 |
| DOI: | 10.1016/j.ejr.2013.02.004 |
| Popis: | IntroductionBehçet’s disease (BD) is an idiopathic multisystem disorder. Cardiac involvement[cardio-BD] occurs in 7–60% of BD patients. Technetium 99m-Methoxyisobutyl isonitrile (Tc-99m sestamibi) is a myocardial perfusion imaging agent that is used for evaluation of the coronary flow.Aim of the workTo evaluate the usefulness of Dipyridamole pharmacological stress test in conjunction with Tc-99m sestamibi cardiac gated single photon emission computed tomography (GSPECT) to investigate the prevalence of subclinical coronary endothelial dysfunction[SCED] in asymptomatic Egyptian BD patients; also to assess possibly associated clinical predictive variables.Patients and MethodsTwenty-five BD patients without overt cardiac involvement and fifteen healthy controls matched for age, BMI and sex were included. Database included full history, clinical examination, relevant laboratory tests, and Tc-99m sestamibi myocardial GSPECT with coronary angiography[CAG] in GSPECT positive cases. Disease activity was assessed using Behçet’s Disease Current Activity Form (BDCAF).ResultsSCED detected by reduced flow or left ventricular dysfunction (LVD) or both was found in 13/25[52%] of BD-patients[12 males and 1 female] vs. 1/15[6.7%] of controls[P |
| Databáze: | OpenAIRE |
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