N-myc gene amplification/expression in localized stroma-rich neuroblastoma (ganglioneuroblastoma)
| Autor: | Gian Paolo Tonini, Cristina Valenti, Giovanna Fabbretti, Massimo Loda, Massimo Brisigotti, Francesco Callea, Cleto Cozzutto |
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| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Genes myc In situ hybridization Biology Pathology and Forensic Medicine Proto-Oncogene Proteins c-myc Neuroblastoma Stroma Gene duplication Gene expression medicine Humans Ganglioneuroblastoma Cytogenetics Gene Amplification Nucleic Acid Hybridization Histology Ganglioneuroma DNA Neoplasm medicine.disease Prognosis Gene Expression Regulation Neoplastic Child Preschool Cancer research Female |
| Zdroj: | Human pathology. 24(3) |
| ISSN: | 0046-8177 |
| Popis: | Using nucleic acid analysis and in situ hybridization we have demonstrated N-myc amplification and expression in two children with a localized (stages I and II) stroma-rich neuroblastoma (NB) (ganglioneuroblastoma). The phenomenon was observed in both undifferentiated and mature ganglion-like cells. The two children are alive and disease-free without any treatment after 16 and 17 months. These observations suggest that morphologic differentiation in NB in vivo is not necessarily followed by a decrease in N-myc expression. Moreover, N-myc amplification does not represent an adverse prognostic factor. In contrast with what happens in undifferentiated NB, N-myc amplification does not have an adverse effect on prognosis when occurring in localized (stages I and II), stroma-rich NB with a favorable histology. |
| Databáze: | OpenAIRE |
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