Pancreatic endocrine cell arrangement during human ontogeny
| Autor: | Sergey Saveliev, Yuliya Krivova, V. M. Barabanov, Alexandra Proshchina |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Somatostatin-Secreting Cells endocrine system medicine.medical_specialty Histology medicine.medical_treatment Cell Embryonic Development Enteroendocrine cell Biology Glucagon Islets of Langerhans 03 medical and health sciences 0302 clinical medicine Insulin-Secreting Cells Internal medicine Diabetes mellitus medicine Humans Endocrine system Pancreas geography geography.geographical_feature_category Insulin Cell Biology General Medicine medicine.disease Islet 030104 developmental biology medicine.anatomical_structure Endocrinology Glucagon-Secreting Cells 030220 oncology & carcinogenesis |
| Zdroj: | Acta Histochemica. 121:638-645 |
| ISSN: | 0065-1281 |
| DOI: | 10.1016/j.acthis.2019.05.010 |
| Popis: | In the human pancreas, various forms of endocrine cell arrangement are found: single endocrine cells, endocrine cell clusters, and mantel, bipolar and mosaic cell (mixed) islets. Our aim was to analyse the distribution and dynamics of insulin-, glucagon- and somatostatin-containing cells within the various forms of endocrine pancreas arrangement during human prenatal development and in adults and to suggest a mechanism of change in the endocrine cell ratio in adult islets. Pancreatic autopsies derived from human foetuses from the 10th to the 40th weeks of development and from adults were examined using histological, immunohistochemical and morphometric methods. During development, the human endocrine pancreas undergoes not only de novo differentiation of endocrine cells and islet formation, but morphogenetic restructuring, which is revealed as a change of the α-, β- and δ-cell ratio in the islets. In particular, increased proportion of glucagon- and somatostatin-containing cells and decreased proportion of β-cells were shown in the largest mosaic islets in adults. Our results indicate that the distribution and proportion of α-, β- and δ-cells depend on the islets size and vascularisation. Studying of the mechanism of such restructuring may contribute to the development of new approaches in the treatment of diabetes mellitus. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect