Administration of Goji (Lycium chinense Mill.) Extracts Improves Erectile Function in Old Aged Rat Model
| Autor: | Sung-Hoo Hong, U-Syn Ha, Seong Bin Hong, Sae Woong Choi, Hyong Woo Moon, Jin Bong Choi, Jeong Ho Geum, Kyu Won Lee, Jung Woo Park, Woong Jin Bae, Sae Woong Kim, Hyun Cheol Jeong, Hyuk Jin Cho |
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| Rok vydání: | 2016 |
| Předmět: |
Aging
medicine.medical_specialty Mean arterial pressure Antioxidant Urology medicine.medical_treatment 030232 urology & nephrology lcsh:Medicine lcsh:RC870-923 Antioxidants Nitric oxide Superoxide dismutase 03 medical and health sciences Lycium chinense chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Pharmacology (medical) Increased serum testosterone level Erectile dysfunction Testosterone biology business.industry Health Policy lcsh:R Public Health Environmental and Occupational Health biology.organism_classification medicine.disease lcsh:Diseases of the genitourinary system. Urology Psychiatry and Mental health Endocrinology Reproductive Medicine chemistry 030220 oncology & carcinogenesis biology.protein Original Article business |
| Zdroj: | The World Journal of Men's Health The World Journal of Men's Health, Vol 35, Iss 1, Pp 43-50 (2017) |
| ISSN: | 2287-4208 |
| Popis: | Purpose: This study investigated the effect of goji (Lycium chinense Mill.) on erectile dysfunction in old-aged rats. Materials and Methods: Twenty-four 18-month-old male Sprague-Dawley rats (defined as old-aged rats) were used. Treatment groups contained eight rats each: a control group, goji extract of 150 mg/kg/day group, and goji extract of 300 mg/kg/day group. Treatment was by orogastric tube once daily for 6 weeks. After 6 weeks of treatment, testes weight, serum testosterone, superoxide dismutase, nitric oxide (NO)-cyclic guanosine monophosphate (cGMP)-related parameters, intracavernous pressure/ mean arterial pressure, and histological changes were examined. Results: Treatments with goji extracts increased serum testosterone level, increased the expression of endothelial NO synthase, neuronal NO synthase, and cGMP, improved the oxidative stress marker, and decreased corporal fibrosis. Conclusions: Our results indicate that goji extract may have a positive effect on erectile dysfunction via its antioxidant effects. |
| Databáze: | OpenAIRE |
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