Association between postoperative acute kidney injury and duration of cardiopulmonary bypass: a meta-analysis
| Autor: | Manish Suneja, Avinash B. Kumar, Michele Tarasi, Emine O. Bayman, Garry D. Weide |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Time Factors Cochrane Library law.invention law medicine Cardiopulmonary bypass Humans Prospective Studies Risk factor Prospective cohort study Retrospective Studies Cardiopulmonary Bypass business.industry Acute kidney injury Retrospective cohort study Acute Kidney Injury medicine.disease Surgery Cardiac surgery surgical procedures operative Anesthesiology and Pain Medicine Treatment Outcome Anesthesia Cohort Cardiology and Cardiovascular Medicine business circulatory and respiratory physiology |
| Zdroj: | Journal of cardiothoracic and vascular anesthesia. 26(1) |
| ISSN: | 1532-8422 |
| Popis: | Objective This meta-analysis examined the association between cardiopulmonary bypass (CPB) time and acute kidney injury (AKI). Design Meta-analysis of previously published studies. Setting Each single-center study was conducted in a surgical intensive care unit and/or academic or university hospital. Participants Adult patients undergoing heart surgery with CPB. Interventions A systematic literature review was conducted using PubMed, EMBASE, and Cochrane Library databases and Google Scholar from January 1980 through September 2009. Initial search results were refined to include human subjects, age >18 years, randomized controlled trials, and prospective and retrospective cohort studies, meet the Acute Kidney Injury Network definition of renal failure, and report times on CPB. Measurements and main results The length of time on CPB has been implicated as an independent risk factor for development of AKI after CPB (AKI-CPB). The 9 independent studies included in the final meta-analysis had 12,466 patients who underwent CPB. Out of these, 756 patients (6.06%) developed AKI-CPB. In 7 of the 9 studies, the mean CPB times were statistically longer in the AKI-CPB cohort compared with the control group (cohort without AKI). The absolute mean differences in CPB time between the 2 groups were 25.65 minutes with the fixed-effects model and 23.18 minutes with the random-effects model. Conclusions Longer CPB times are associated with a higher risk of developing AKI-CPB, which, in turn, has a significant effect on overall mortality as reported by the individual studies. |
| Databáze: | OpenAIRE |
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