Protective effects of mito-TEMPO against doxorubicin cardiotoxicity in mice
| Autor: | Ayling Martins Ng, Cintia Figueiredo de Araújo, Candace Machado de Andrade, Alberto A. Noronha-Dutra, Viviane Costa Junqueira Rocha, André Cronemberger Andrade, Mariana da Cruz Borges-Silva, Simone Garcia Macambira, Luciana Souza de Aragão França, Lain Pontes-de-Carvalho, Emanuelle de Souza Santos |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Cancer Research Cardiotonic Agents medicine.medical_treatment Mitochondrion Pharmacology Toxicology Mitochondria Heart Lipid peroxidation Mice 03 medical and health sciences chemistry.chemical_compound Organophosphorus Compounds Piperidines Malondialdehyde polycyclic compounds medicine Animals Pharmacology (medical) Doxorubicin Creatine Kinase Saline Cardiotoxicity Antibiotics Antineoplastic Dose-Response Relationship Drug biology business.industry Mice Inbred C57BL carbohydrates (lipids) 030104 developmental biology Oncology chemistry biology.protein Female Creatine kinase Lipid Peroxidation business Doxorubicin cardiotoxicity Injections Intraperitoneal medicine.drug |
| Zdroj: | Cancer Chemotherapy and Pharmacology. 77:659-662 |
| ISSN: | 1432-0843 0344-5704 |
| DOI: | 10.1007/s00280-015-2949-7 |
| Popis: | Doxorubicin (DOX) is a chemotherapeutic that is widely used for the treatment of many human tumors. However, the development of cardiotoxicity has limited its use. The aim of the present study was to evaluate the possible efficacy of mito-TEMPO (mito-T) as a protective agent against DOX-induced cardiotoxicity in mice. C57BL/6 mice were treated twice with mito-T at low (5 mg/kg body weight) or high (20 mg/kg body weight) dose and once with DOX (24 mg/kg body weight) or saline (0.1 mL/20 g body weight) by means of intraperitoneal injections. The levels of malondialdehyde (MLDA), a marker of lipid peroxidation, and serum levels of creatine kinase were evaluated 48 h after the injection of DOX. DOX induced lipid peroxidation in heart mitochondria (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink