High B7‐H3 expression is linked to increased risk of prostate cancer progression

Autor:	Guido Sauter, Sarah Bonk, Ronald Simon, Katharina Möller, Doris Höflmayer, Thorsten Schlomm, Georgia Makrypidi-Fraune, Andrea Hinsch, Sebastian Dwertmann Rico, Pinar Tasdelen, Martina Kluth, Markus Graefen, Andreas M. Luebke, Hans Heinzer, Claudia Hube-Magg, Sarah Minner, Franziska Büscheck, Sören Weidemann, David Dum, Ria Uhlig
Rok vydání:	2020
Předmět:	Male Risk 0301 basic medicine Pathology medicine.medical_specialty B7 Antigens TMPRSS2 Pathology and Forensic Medicine Cohort Studies 03 medical and health sciences Prostate cancer 0302 clinical medicine Prostate medicine Humans Aged Oncogene business.industry Serine Endopeptidases Prostatic Neoplasms General Medicine Middle Aged Prostate-Specific Antigen Prognosis medicine.disease Immunohistochemistry Androgen receptor 030104 developmental biology medicine.anatomical_structure Receptors Androgen Tissue Array Analysis 030220 oncology & carcinogenesis Disease Progression Cancer research Kallikreins Neoplasm Grading business Erg Immunostaining
Zdroj:	Pathology International. 70:733-742
ISSN:	1440-1827 1320-5463
DOI:	10.1111/pin.12999
Popis:	B7-H3 is a member of the B7 superfamily of immune checkpoint molecules. B7-H3 up regulation has been linked to cancer development and progression in many tumors including prostate cancer. To clarify the potential utility of B7-H3 as a prognostic biomarker, B7-H3 expression was analyzed by immunohistochemistry in more than 17 000 prostate cancers. Normal prostatic glands were largely B7-H3 negative, while membranous B7-H3 immunostaining was seen in 47.0% of analyzed cancers. B7-H3 immunostaining was weak in 12.3%, moderate in 21.1% and strong in 13.5% of cases. High B7-H3 expression was associated with pT, Gleason score, lymph node metastasis, high Ki67 labeling index and early prostate-specific antigen recurrence (P < 0.0001 each). High B7-H3 expression was also linked to high androgen receptor expression and TMPRSS2:V-ets avian erythroblastosis virus E26 oncogene homolog (ERG) fusions (P < 0.0001 each). Multivariate analyses showed a strong independent prognostic impact of high B7-H3 expression in all cancers and in the ERG negative subgroup. Comparison with previously analyzed frequent chromosomal deletions revealed a close association with Phosphatase and Tensin Homolog deletions. Analysis of B7-H3, alone or in combination with other markers, might be of clinical utility, especially in the subgroup of ERG negative prostate cancers.
Databáze:	OpenAIRE
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