Retrospective evaluation of patients diagnosed solid pseudopapillary neoplasms of the pancreas
| Autor: | Ayse Ocak Duran, Ozlem Ercelep, Serkan Menekse, Ozgur Tanriverdi, Burcu Yapar Taskoylu, Melike Ozcelik, Mahmut Gumus, Nuriye Ozdemir, Mukremin Uysal, Asude Aksoy, Turkan Ozturk Topcu, Umut Demirci, Zuhat Urakci, Nedim Turan |
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| Přispěvatelé: | MÜ |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Cancer Research Survival recurrent disease retrospective study Perineural invasion jaundice Metastasis 0302 clinical medicine distant metastasis Pancreatic tumor cancer diagnosis middle aged Neoplasm distal pancreatectomy cancer survival Lymph node antineoplastic agent clinical article lymph node metastasis adult Middle Aged perineural invasion Prognosis humanities backache adjuvant chemotherapy Survival Rate aged medicine.anatomical_structure female Oncology 030220 oncology & carcinogenesis Lymphatic Metastasis Solid pseudopapillary Neoplasm Pancreatic Tumor young adult Female Radiology Pancreas headache Adult medicine.medical_specialty Adolescent abdominal distension overall survival Article pancreas tumor peritoneum metastasis Young Adult 03 medical and health sciences Pancreatectomy medicine cancer radiotherapy follow up Humans solid pseudopapillary tumor Neoplasm Invasiveness human Survival rate Aged Retrospective Studies Carcinoma Papillary/*secondary/surgery Follow-Up Studies Pancreatectomy/*mortality Pancreatic Neoplasms/*pathology/surgery business.industry abdominal pain Retrospective cohort study pruritus tumor invasion medicine.disease mortality Carcinoma Papillary clinical feature Treatment Pancreatic Neoplasms stomatognathic diseases liver metastasis 030104 developmental biology cancer recurrence tumor volume pathology business papillary carcinoma |
| Popis: | PubMed ID: 30104029 Purpose: Solid pseudopapillary neoplasm (SPN) is a rare, low-grade neoplasm with excellent prognosis. In this study, we evaluated clinicopathological characteristics of patients diagnosed with SPN retrospectively. Methods: This is a retrospective study intended to characterize patients with the diagnosis of SPN between 2005 and 2015. Clinicopathological features, recurrence rate, and overall survival of 28 patients were recorded. Malignant SPN criteria were defined as the presence of distant metastasis (developed at diagnosis or during follow up) or lymph node involvement. Results: The mean age at diagnosis was 42 (range: 17-41). Among patients, 82% (n = 23) were female and 17.9% (n = 5) were male. The mean size of tumor was 5.81 cm (range: 2-15). The mean follow up period was 55.6 months, 1-year survival was 96.5% and 5-year survival rate was 88%. A total of 25 patients were alive at the end of follow-up period and 3 of the patients became exitus due to disease. Two patients had a metastatic presentation in livers at the diagnosis and metastasis developed in 3 patients during follow-up (liver of 1 patient, peritoneum in 1 patient and liver and peritoneum in 1 patient). The reason of admission was headache in 68% patients. The type of operation was frequently subtotal pancreatectomy (n = 11, 39.3%) and distal pancreatectomy (n = 10, 35.7%). Tumors were located frequently in body and tail regions (n = 18, 64.3%) and the number of patients with malignant criteria was 6 (21.4%). Although the mean age of malignant patients was significantly higher than benign patients (P = 0.046), there was no significant difference between 2 groups in terms of gender, tumor size, capsule invasion, perineural invasion, vascular invasion, and margin status. Conclusion: SPN is a rarely seen tumor with low malignity potential. Surgical resection provides long-term survival rate even in local invasion or metastasis conditions. © 2018 Elsevier Inc. |
| Databáze: | OpenAIRE |
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