Challenge in Understanding Size and Shape Dependent Toxicity of Gold Nanomaterials in Human Skin Keratinocytes

Autor:	Paresh Chandra Ray, Shuguang Wang, Uma Shanker Rai, Wentong Lu, Oleg Tovmachenko, Hongtao Yu
Rok vydání:	2013
Předmět:	Chemistry General Physics and Astronomy Nanoparticle Nanotechnology Human skin engineering.material Article Nanomaterials Coating Colloidal gold Toxicity engineering Nanorod Physical and Theoretical Chemistry Cytotoxicity
Zdroj:	Chemical physics letters. 463(1-3)
ISSN:	0009-2614
Popis:	As the nanotechnology field continues to develop, assessing nanoparticle toxicity is very important for advancing nanoparticles for biomedical application. Here we report cytotoxicity of gold nanomaterial of different size and shape using MTT test, absorption spectroscopy and TEM. Spherical gold nanoparticles of different sizes are not inherently toxic to human skin cells, but gold nanorods are highly toxic due to the presence of CTAB as coating material. Due to toxicity of CTAB, and aggregation of gold nanomaterials in the presence of cell media, we have demonstrated that it is difficult to understand the cytotoxicity of gold nanomaterials individually.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929c65f62d67f041012b4121d9c7faec https://pubmed.ncbi.nlm.nih.gov/24068836 Zobrazit plný text záznamu Full Text from ScienceDirect