Hepatitis B surface antigen reactivity in man due to a new variant of hepatitis B virus
| Autor: | R. N'Doye, C. Molinie, Y. Busson, J. Chotard, C. Bourdil, J. P. Chiron, I. Diop-Mar, B. Yvonnet, Pierre Coursaget |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Hepatitis B virus HBsAg Hepatitis B vaccine Hepatitis B virus DNA polymerase Cross Reactions medicine.disease_cause Antigen medicine Humans Hepatitis B e Antigens Child Hepatitis B Surface Antigens General Veterinary General Immunology and Microbiology biology Public Health Environmental and Occupational Health Genetic Variation Infant virus diseases Hepatitis B biology.organism_classification Virology Senegal digestive system diseases Infectious Diseases Hepadnaviridae HBeAg Child Preschool DNA Viral Immunology biology.protein Molecular Medicine France Antibody |
| Zdroj: | Vaccine. 8:S15-S17 |
| ISSN: | 0264-410X |
| Popis: | A new type of hepatitis B virus (HBV) infection has been encountered in Senegalese infants and French adults characterized by serum hepatitis B surface antigen (HBsAg) without antibodies to the core antigen (anti-HBc). As the infection is not associated with the presence of the e antigen, it differs from HBV in its core antigen. After teh loss of HBsAg, neither anti-HBs not antibodies to HBsAg (anti-HBs) become detectable. This new infection (called HBV 2 as opposed to the classical HBV 1 infection) was found in infants with anti-HBs, either naturally acquired or produced by immunization against HBV. The use of monoclonal anti-HBs antibodies showed that two epitopes of HBV 1 surface antigen could be detected in HBV 2 -positive sera. HBV DNA sequences could only be found in one of 15 HBV 2 -infected children using a DNA-DNA hybridization proceduer; low levels of HBV DNA were also detected in 58% of the HBsAg-positive adult sera tested. if this new infection, apparently related to HBV 1 , is shown to cause chronic liver disease, hepatitis B vaccine should also contain surface antigen from HBV 2 . |
| Databáze: | OpenAIRE |
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