Biomimetic composite microspheres of collagen/chitosan/nano-hydroxyapatite: In-situ synthesis and characterization

Autor: Yong Luo, Shu-Hua Teng, Peng Wang, Mian-Hui Liang
Rok vydání: 2016
Předmět:
Zdroj: Materials Science and Engineering: C. 58:610-613
ISSN: 0928-4931
DOI: 10.1016/j.msec.2015.09.021
Popis: The collagen/chitosan/hydroxyapatite (COL/CS/HA) composite microspheres with a good spherical form and a high dispersity were successfully obtained using an in-situ synthesis method. The FT-IR and XRD results revealed that the inorganic phase in the microspheres was crystalline HA containing carbonate ions. The morphology of the composite microspheres was dependent on the HA content, and a more desirable morphology was achieved when 20 wt.% HA was contained. The composite microspheres exhibited a narrow particle distribution, most of which ranged from 5 to 10 μm. In addition, the needle-like HA nano-particles were uniformly distributed in the composite microspheres, and their crystallinity and crystal size decreased with the HA content.
Databáze: OpenAIRE