The response of institutionalized Down's syndrome subjects to enterovirus infections
| Autor: | C. R. Boughton, R. A. Hawkes, Susan C. Philbrook |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Adult
Serotype Adolescent viruses Immunology Prevalence Biology Antibodies Viral medicine.disease_cause complex mixtures Virus Enterovirus Infections medicine Humans Child Poliovirus Public Health Environmental and Occupational Health Institutionalization medicine.disease Virology Poliomyelitis Vaccination Immunization Child Preschool Poliovirus Vaccine Oral biology.protein Down Syndrome Antibody Research Article |
| Zdroj: | Journal of Hygiene. 84:433-441 |
| ISSN: | 0022-1724 |
| DOI: | 10.1017/s0022172400026978 |
| Popis: | SUMMARYIn a study comparing the responses of institutionnalized Down's syndrome (DS) and non-Down's (ND) inmates to enterovirus infections, the frequency of wild enteric viruses and the excreation patterns of oral polio vaccine (OPV) viruses were similar in both groups. Antibody titres developed to poliovirus types 2 nad 3 following vaccination were similar in DS and ND and ND vaccinees, but the responses to type I virus was signifcantly less in DS vaccinees. As judged by the development of poliovirus antibody in non-vaccinees, the spread of virus from OPV-immunized to unimmunized subjects in the institution was not noticeably different in DS and ND subjects.An unexpected finding was that the excretion patterns of all three serotypes of poliovirus were strikingly similar for each individual to individual. The similarity of excreation occurred despite wide differences within an individual in the titres of neutralizing serum antibodies to the three serotypes. It is suggested that the rate at which a given individual eliminates enteroviruses may be largely determined by factors, the activities of which atre not reflected in serum antibody titres. |
| Databáze: | OpenAIRE |
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