Therapeutic plasma exchange for neuromyelitis optica spectrum disorder: A multicenter retrospective study by the ASFA neurologic diseases subcommittee
| Autor: | Yanyun Wu, Leonor P Fernando, Jay S. Raval, Tina S. Ipe, Chisa Yamada, Amit Gokhale, Huy P. Pham, Andrew D. Johnson, Amy E. Schmidt, Joseph E. Schwartz, Cyril Jacquot, Monica B. Pagano, Shanna Morgan, Haewon C. Kim, Yunchun D. Mo, Edward C.C. Wong, Amy Waldman, Grace Monis, Jeffrey L. Winters, Jennifer Webb, Kimberly W. Sanford |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty Adolescent Disease 030204 cardiovascular system & hematology Young Adult 03 medical and health sciences 0302 clinical medicine medicine Humans In patient Spectrum disorder Registries Child Adverse effect Aged Autoantibodies Retrospective Studies Aged 80 and over Neuromyelitis optica Plasma Exchange business.industry Neuromyelitis Optica Infant Newborn Infant Retrospective cohort study Plasmapheresis Hematology General Medicine Middle Aged medicine.disease Response to treatment United States Child Preschool Blood Component Removal Therapeutic plasma exchange business 030215 immunology |
| Zdroj: | Journal of Clinical Apheresis. 35:25-32 |
| ISSN: | 1098-1101 0733-2459 |
| DOI: | 10.1002/jca.21754 |
| Popis: | Importance Neuromyelitis optica/neuromyelitis optica spectrum disorder patients' response to therapeutic plasma exchange (TPE) is currently incompletely characterized. Objective Our study aims to understand the clinical status improvement of neuromyelitis optica/neuromyelitis optica spectrum disorder patients treated with TPE. Design, setting, and participants This is a multicenter retrospective study conducted between 1 January 2003 and 31 July 2017 at 13 US hospitals performing apheresis procedures. Subjects studied were diagnosed with neuromyelitis optica/neuromyelitis optica spectrum disorder who received TPE during presentation with acute disease. Main outcomes and measures The primary outcome was clinical status improvement in patients treated with TPE. Secondary measures were procedural and patient characteristics associated with response to treatment. Results We evaluated 114 patients from 13 institutions. There was a female predilection. The largest ethnic group affected was non-Hispanic Caucasian. The average age of diagnosis was 43.1 years. The average time to diagnosis was 3.1 years. On average, five procedures were performed during each treatment series. The most commonly performed plasma volume exchange was 1.0 to 1.25 using 5% albumin as replacement fluid. Most patients (52%) did not require an additional course of TPE and noted "mild" to "moderate" clinical status improvement. Maximal symptom improvement appeared by the fourth or fifth TPE treatment. Conclusion and relevance TPE improved the clinical status of patients. Adults responded more favorably than children. Procedural characteristics, including number of TPEs, plasma volume exchanged, and replacement fluid used, were similar between institutions. TPE was well-tolerated and had a low severe adverse event profile. |
| Databáze: | OpenAIRE |
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