Randomized Trial on the Effectiveness of Dexamethasone in TMJ Arthrocentesis
| Autor: | L.M. Vos, J.J.R. Huddleston Slater, L.P.P. Stroy, Boudewijn Stegenga |
|---|---|
| Přispěvatelé: | Personalized Healthcare Technology (PHT) |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_treatment Anti-Inflammatory Agents Osteoarthritis Mandible Dexamethasone law.invention Injections Intra-Articular Placebos Eating Randomized controlled trial law Paracentesis Range of Motion Articular Pain Measurement PLACEBO Remission Induction PAIN Temporomandibular Joint Disorders TEMPOROMANDIBULAR-JOINT medicine.anatomical_structure Treatment Outcome Anesthesia lavage Female KNEE Range of motion RCT medicine.drug Adult musculoskeletal diseases CORTICOSTEROIDS Placebo Double-Blind Method stomatognathic system medicine ARTHROSCOPIC LAVAGE Humans arthralgia General Dentistry Glucocorticoids business.industry TMD Arthrocentesis medicine.disease Temporomandibular joint stomatognathic diseases OSTEOARTHRITIS Arthroscopic lavage Mastication DISC DISPLACEMENT business Follow-Up Studies |
| Zdroj: | Journal of Dental Research, 91(2), 173-178. SAGE Publications Inc. |
| ISSN: | 0022-0345 |
| Popis: | The aim of this study was to compare the effectiveness of dexamethasone administration following arthrocentesis of the temporomandibular joint (TMJ) with a placebo (saline). Twenty-eight participants with TMJ arthralgia were randomly assigned to two groups of a parallel double-blind RCT. In both groups, an arthrocentesis procedure was carried out. In one group, the procedure was followed by the administration of a single-dose intra-articular dexamethasone. In the other group, saline was administered as a control. Follow-up visits were scheduled after 1, 3, and 24 weeks. During each visit, TMJ pain (on a 100-mm VAS) and jaw stiffness (mouth opening in mm) were scored. In the statistical analysis, generalized estimating equation (GEE) models showed no differences between the two study groups, although pain and jaw stiffness were both reduced over 24 weeks. In conclusion, intra-articular dexamethasone following arthrocentesis did not improve the procedure’s effect in patients presenting with TMJ arthralgia (ClinicalTrials.gov number CT01275014). |
| Databáze: | OpenAIRE |
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