Male reproductive toxicity study of nefiracetam in rats
| Autor: | Mamoru Nomura, Shigeo Harada, Koji Kakihata, Satoshi Takayama, Makoto Shimada, Kunio Matsuhashi, Yukari Sakaguchi |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Testicle Biology Toxicology Drug Administration Schedule Rats Sprague-Dawley Atrophy Oral administration Internal medicine medicine Animals Infertility Male Psychotropic Drugs Dose-Response Relationship Drug medicine.disease Sperm Pyrrolidinones Rats Dose–response relationship Fertility Endocrinology medicine.anatomical_structure Nefiracetam Toxicity Reproductive toxicity medicine.drug |
| Zdroj: | The Journal of Toxicological Sciences. 20:309-317 |
| ISSN: | 1880-3989 0388-1350 |
| DOI: | 10.2131/jts.20.309 |
| Popis: | Sprague-Dawley male rats were administered nefiracetam orally at daily doses of 500 and 1500 mg/kg/day for 4 or 9 weeks. Although the copulation index was not affected by nefiracetam treatment, the fertility index was extremely low in the 1500 mg/kg/day group for both treatment periods. This high dose group consistently exhibited decreased testicular weights. Epididymal and prostate weights were also reduced in the 1500 mg/kg/day group after both 4- and 9-week treatments and in the 500 mg/kg/day group after the 9-week treatment. Severe degenerative changes such as degeneration of germ cells, loss of germ cells and atrophy of seminiferous tubules were observed in all rats of the 1500 mg/kg/day groups after both 4 and 9 weeks of treatment. Retention of spermatids in stage IX, X and XI seminiferous tubules was also noted after the 4- and 9-week treatments at 500 mg/kg/day. The testicular sperm head counts were markedly decreased following the 4- and 9-week treatments at 1500 mg/kg/day, and mildly reduced after the 4-weeks treatment at 500 mg/kg/day. From these results it is concluded that histopathological examination and the testicular sperm head count method are highly useful for detecting testicular toxicity and that testicular lesions caused by nefiracetam can be detected after 4 weeks of exposure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|