Prophylaxis of Migraine with Anionic Polyelectrolytes
| Autor: | Llewellyn B. Bigelow, Ernst Thonnard-Neumann |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Male Migraine Disorders medicine.medical_treatment Heparinoid Basophil Polysaccharides Administration Inhalation medicine Humans Pentosan Sulfuric Polyester Clinical Trials as Topic Chemotherapy Leukopenia Heparin business.industry Middle Aged Pentosan polysulfate medicine.disease medicine.anatomical_structure Neurology Migraine Anesthesia Drug Therapy Combination Female Neurology (clinical) medicine.symptom Headaches business medicine.drug |
| Zdroj: | Headache: The Journal of Head and Face Pain. 28:114-120 |
| ISSN: | 1526-4610 0017-8748 |
| DOI: | 10.1111/j.1526-4610.1988.hed2802114.x |
| Popis: | SYNOPSIS In previous studies on patients with migraine headaches we found that 50% had reduced concentrations of basophils and lymphocytes. Treatment with inhalations of heparin often restored these blood indices to normal and was accompanied by a reduction in migraine headache, We report here data on the long term treatment of 37 migraine patients with inhalations of heparin and with an oral semi-synthetic heparinoid, Pentosan Polysulfate (PNP). 27 patients responded with a mean improvement in migraine index of 79% and as a group showed significant increases in basophil, total lymphocyte, and in particular T-cell concentrations. Ten patients whose migraine headaches were related to their menstrual cycles were relatively unresponsive to heparin or PNP. They had a general leukopenia, but basophils were within normal range. |
| Databáze: | OpenAIRE |
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