The prognostic value of PKM2 and its correlation with tumour cell PD-L1 in lung adenocarcinoma

Autor: Hao Hu, Qian Zhu, Yu-Kang Kuang, Chang-Ying Guo, Xiao-Ming Wen, Fang-Fang Tou
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Oncology
Male
Lung adenocarcinoma
Cancer Research
Lung Neoplasms
B7-H1 Antigen
0302 clinical medicine
Surgical oncology
Programmed death ligand 1
Pyruvate kinase M2
Prognostic factor
medicine.diagnostic_test
biology
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Gene Expression Regulation
Neoplastic
medicine.anatomical_structure
030220 oncology & carcinogenesis
Adenocarcinoma
Female
Research Article
Adult
medicine.medical_specialty
Thyroid Hormones
Subgroup analysis
Adenocarcinoma of Lung
lcsh:RC254-282
Disease-Free Survival
Flow cytometry
03 medical and health sciences
Internal medicine
PD-L1
Cell Line
Tumor
Genetics
medicine
Biomarkers
Tumor
Humans
Survival analysis
Aged
Proportional Hazards Models
Lung
business.industry
Proportional hazards model
Membrane Proteins
medicine.disease
030104 developmental biology
biology.protein
business
Carrier Proteins
Zdroj: BMC Cancer, Vol 19, Iss 1, Pp 1-12 (2019)
BMC Cancer
ISSN: 1471-2407
DOI: 10.1186/s12885-019-5519-2
Popis: Background The prognostic value of PKM2 and its correlation with tumour cell PD-L1 in lung adenocarcinoma (LUAD) is unclear. Methods A total of 506 lung adenocarcinoma samples from The Cancer Genome Atlas (TCGA) dataset and 173 LUAD tumour tissues from Jiangxi Cancer Hospital were used to analyse the correlation between PKM2 and PD-L1 expression. We further established a stable LUAD cell line with PKM2 knockdown and confirmed the association via Western blotting and flow cytometry analysis. Moreover, the prognostic values of PKM2 and PD-L1 were evaluated by the Kaplan-Meier method and Cox proportional hazards models. Results Based on the above two large cohorts, we found that PKM2 was significantly positively associated with PD-L1 expression (r = 0.132, P = 0.003 and r = 0.287, P
Databáze: OpenAIRE
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